The pharmacokinetics and development of antinuclear antibodies (ANAs) during procainamide (PA) therapy were studied in 35 patients with ventricular arrhythmias. Sixteen of the subjects were rapid and 19 were slow acetylators. Twenty-six of them (13 rapid and 13 slow acetylators) received PA ...
Adverse Effects Many adverse effects of amitriptyline and similar tricy- clic antidepressants are caused by their antimuscarinic actions. Antimuscarinic effects are relatively common and occur before an antidepressant effect is obtained. They include dry mouth, constipation occasionally leading to paralytic ...
Positive inotrope with direct pulmonary vasodilator (decrease both preload & afterload) activity, which increases cardiac output; these effects result from increases in cellular levels of cAMP as inamrinone inhibits myocardial cAMP phosphodiesterase Pharmacokinetics Half-Life: 3.6-5.8 hr (longer in CHF) ...
Controlled lactation studies have not been conducted in humans; however tacrolimus has been reported to be present in human milk; effects of tacrolimus on breastfed infant, or on milk production have not been assessed Tacrolimus is excreted in rat milk and in peri-/postnatal rat studies, exposure...
Therefore, we conducted a study of a large population of Medicare enrollees cared for in the ambulatory setting to evaluate the incidence and preventability of adverse drug events among ambulatory geriatric patients; to categorize adverse drug events by drug class, severity, and clinical effects; ...
Adverse events and adverse drug reactions are common in clinical practice. Side effects range from the common to the rare and may be confused with other mucocutaneous manifestations resulting from several medications to treat infections, other medical co
Sodium-channel blocker: procainamide systemic lupus neutropeniacardiotoxicity sodium-channel blocker: lidocaine CNS effectsrespiratory arrest potassium-channel blocker: amiodarone pulmonary toxicitysinus bradycardiaAV blockvisual disturbancesphlebitishypotension adenosine chest painshortness of breathtinglingworsening dysrh...
worse, tell your doctor promptly.To reduce the risk of dizziness and lightheadedness, get up slowly when rising from a sitting or lying position.Remember that this medication has been prescribed because your doctor has judged that the benefit to you is greater than the risk of side effects. ...
AVOID in pt with known prolongation of QT, uncorrected hypoK, pt receiving Class IA (quinidine, procainamide), Class III (amiodarone, sotalol) antiarrhythmic agents Elderly pt more susceptible to drug-associated effects on QT interval FQ effect on Blood Glucose FQ mildly block pancreatic B-cell ...
When lidocaine is administered with other antiarrhythmic drugs such as amiodarone, phenytoin, procainamide, propranolol or quinidine, the cardiac effects may be additive or antagonistic and toxic effects may be additive Coadministration of propranolol or cimetidine with lidocaine has been reported to reduce...