, and two are physicians specialized in clinical pharmacology (P. Th., S. Sch.). Details of the experts can be found in an additional file (see Additional file 4). Due to resource limitations, each overview was assessed by one reviewer. Utility assessment The overall agreement with the...
Small increases in total mortality were noted in patients with diabetes and nonocular hemorrhagic events were apparent in patients with age-related macular degeneration. Meaning The findings of this systematic review with meta-analysis suggest that intravitreal anti-VEGF drugs were not associated with ...
Meaning This study suggests that clinicians should be aware of potentially severe adverse events associated with corticosteroid bursts in children. Abstract Importance The adverse effects from the long-term use of oral corticosteroids are known, but, to our knowledge, few studies have reported the risk...
There has been much less work on developing algorithms in individuals of African ancestry than in other populations [57]. A systematic review has shown that variants which are more prevalent in Black Africans have functional effects which are equivalent to those seen in White individuals [58], ye...
Keynote review: in vitro safety pharmacology profiling: an essential tool for successful drug development. Drug Discov Today. 2005;10(21):1421–33. 40. Cao D-S, Xiao N, Li Y-J, Zeng W-B, Liang Y-Z, Lu A-P, Xu Q-S, Chen A. Integrating multiple evidence sources to predict ...
Adverse patient safety events, unintended injuries resulting from medical therapy, were associated with 110,000 deaths in the United States in 2019. A nationwide pandemic (such as COVID-19) further challenges the ability of healthcare systems to ensure s
Clarification of genetic susceptibility factors for ADRs is clearly of fundamental importance, and such knowledge extends our understanding of pharmacology, genetics and immunology. Beyond such intrinsic value, however, will it ever be possible to routinely apply such knowledge to predict and prevent occu...
"It's basically a credit card-sized card with a magnetic strip containing all the important genetic data on a particular patient," explains one of the study's co-authors Magnus Ingelman-Sundberg, professor of molecular toxicology at the Department of Physiology and Pharmacology at Karolinska Instit...
Meaning Findings of this study suggest that resumption of ICI therapy could be considered for select patients, with appropriate monitoring and use of standard treatment algorithms to identify and treat toxic effects. Abstract Importance Limited information is available on the safety of a rechallenge with...
Effects of early life stress on cognitive and affective function: an integrated review of human literature. Psychopharmacology (Berl). 2011;214(1):55-70. doi:10.1007/s00213-010-2009-2 PubMedGoogle ScholarCrossref 16. Seeley WW, Menon V, Schatzberg AF, et al. Dissociable...