adverse drug effect ad·verse drug re·ac·tion (ADR)(ad-vĕrs' drŭg rē-ak'shŭn) Any noxious, unintended, and undesired effect of a drug after its administration for prophylaxis, diagnosis, or therapy. Synonym(s):adverse drug effect. ...
ACE Inhibitors, Angiotensin II Antagonists, Antihypertensives and Anti-Psychotics: May increase the hypertensive effects of thiopental. Some Phenothiazines, especially Promethazine: Can increase excitatory phenomena produced by thiopental. Cyclizine: May have a similar effect. Opiates: Can potentiate CNS dep...
Effects of food Oral suspension: When administered with food, peak plasma concentration increased by 56% and AUC unchanged Tablets: No effect Distribution Protein bound: 51% (0.02 mcg/mL); 7% (2 mcg/mL) Elimination Clearance: 630 mL/min (single 500-mg oral and IV dose) ...
promethazine protriptyline quazepam quetiapine quinine quizartinib ranolazine repaglinide rifapentine rilpivirine ripretinib risperidone roflumilast roflumilast topical rucaparib saxagliptin seladelpar selpercatinib sertraline sildenafil sodium sulfate/potassium chloride/magnesium sulfate/polyethylene glycol sofosbuvir/...
Potassium Dehydroandrograpolide Succinate Injection Glucose Injection 400mg+5% intravenous drip, 2 cases on the use of 7min and 10min after feeling chest tightness, dyspnea, chills, fever, skin itching and other symptoms. Withdrawal immediately, oxygen inhalation, promethazine injection, dexamethasone ...
19–25 but the effect of a poor metabolizer phenotype on pain relief from oxycodone and hydrocodone is less clear.26–30 In addition, the impact of CYP2D6 variants on mild, nonlife threatening, adverse reactions associated with opioids (e.g., nausea), and subsequent effects on pain control ...
paclitaxel, pancuronium, penicillin G, phenytoin, piperacillin-tazobactam, prochlorperazine, promethazine, propofol, quinupristin-dalfopristin, ranitidine, remifentanil, sargramostim, tacrolimus, teniposide, theophylline, thiotepa, ticarcillin-clavulanate, tobramycin, vancomycin, vecuronium, vinorelbine, zidovudin...
~30% of administered dose is converted to inactive metabolites during first-pass effect associated with drug absorption from the gut Hepatic metabolized by CYP2D6 (major), CYP1A2 (minor), and CYP2C19 (minor) Elimination Half-life: ~12 hr Half-life, terminal: 11-13 hr (first dose); 17-22...
Opioid-induced hyperalgesia (OIH) occurs when opioid analgesic paradoxically causes increase in pain, or increase in sensitivity to pain; this condition differs from tolerance, which is the need for increasing doses of opioids to maintain a defined effect Symptoms include (but may not be limited ...
Administering a subject composition to an animal, such as a human being, who has an adverse effect associated with taking a medication, has a profound effect of keeping the body in its best possible health condition. When the human body is in a pH state of 7.4 it is more resistant to ha...