In their next publication, using levodopa, Cotzias et al. (1969) now listed mental effects and involuntary movements, in addition to anorexia, nausea, and vomiting. The mental effects listed were irritability, anger, hostility, paranoia, insomnia, and an awakening effect. The dyskinesias were ...
Adverse Effects and Treatment The most important adverse effect of ethambutol is ret- robulbar neuritis with a reduction in visual acuity, con- striction of visual field, central or peripheral scotoma, and green-red colour blindness. One or both eyes may be affected. The degree of visual ...
Parkinson’s disease (PD) is a progressive neurological condition that causes considerable disability in the elderly. Drugs used to treat PD, such as levodopa, offer symptomatic relief but often have neuropsychiatric adverse effects, most prominently psychosis and delirium. Aged patients and those with...
Sudden death in a number of patients receiving methyldopa has been associated with myocarditis (of- ten with hepatitis and pneumonitis).1,2 The effect is thought to be due to hypersensitivity. Hypersensitivity myocarditis is generally marked by ECG changes, a slight rise in cardiac enzymes, cardi...
The case reported here illustrates a common pharmacodynamic drug interaction of haloperidol with levodopa in a 60-year-old female patient. 展开 关键词: Adverse drug interaction haloperidol levodopa parkinsonism DOI: 10.4103/0253-7176.155636 被引量: 1 ...
effect is a summation of the effects from the individual drugs, whereas synergism occurs when the overall pharmacological effect ofthe combination is greater than additive, and antagonism occurs when the drug combination effect is less than the additive effect[69]. For example,thiazide diureticssuch...
Adverse Effect Malpractice An injury caused by medical management—rather than by the underlying disease—which prolongs hospitalization, produces a disability at the time of discharge, or both. Aetiology Drug effects, wound infections, technical complications, negligence, diagnostic or therapeutic mishaps,...
effect observed at the in vivo level. They can be developed by linking the MIE and subsequent KEs to an observed final AO, or through predicting the AO from a known MIE and KE series. An understanding of the pathogenesis of an AOP is fundamental for identifying KEs, and as information on...
Monitoring of Blood L-DOPA and L-DOPA Metabolite Concentrations and Adverse Events in Patients with Advanced Parkinson's Disease Receiving L-DOPA and MAO Inhibitor Selegiline ((-)Deprenyl) Combination Therapy : A Clinical Study SATOH Mitsutoshi , TSURUOKA Yumi , KUZUU Ami , DOI Hirokazu , MASAK...
Positive evidence of human fetal risk. X: Do not use in pregnancy. Risks involved outweigh potential benefits. Safer alternatives exist. NA: Information not available.Pharmacology Mechanism of Action Direct vasodilator; dilates arterioles with little effect on vein; decreases systemic resistance, which...