We assessed whether interactions between hippocampal glutamatergic function and activity/striatal connectivity are associated with adverse clinical outcomes in people at clinical high-risk (CHR) for psychosis. We measured functional Magnetic Resonance Imaging of hippocampal activation/connectivity, andH-Magnetic...
Translational Psychiatry www.nature.com/tp ARTICLE OPEN Adverse clinical outcomes in people at clinical high-risk for psychosis related to altered interactions between hippocampal activity and glutamatergic function Paul Allen1,2,3,16, Emily J. Hird 2,4,16 ✉, Natasza Orlov2,5,6,7, Gemma ...
To date, however, associations between neuroimaging measures and clinical outcomes in CHR samples have largely been identified in studies of a single neuroimaging metric. Yet, contemporary models emphasise the interrelated nature of physiological and neurochemical dysfunction in the hippocampus, and its int...
Aim To assess the impact of socioeconomic deprivation (as categorised by Scottish Index of Multiple Deprivation, SIMD) on the medical management and clinical outcomes of patients with ACS (NSTEMI/STEMI) who were treated with PCI Methods A retrospective study of NSTEMI/NSTEMI patients after ...
failure outcomes individually, and an aggregate of the emergency department and inpatient encounters, termed serious treatment failure. 主要结局是治疗失败,这是入组后 1 至 14 天评估的总体结局。 选择结果窗口是为了记录治疗期间和治疗完成后不久的治疗失败,因为最近的数据表明,80% 的儿科患者接受为期 10 天...
Clinical data of patients were collected through the data platform of China Heart Failure Center. The multivariate Logistic regression analysis was used to analyze the influencing factors of adverse outcomes in patients with CHF. A risk prediction model was constructed, the goodness of fit and ...
We assessed potential effect modification of the association between ED and clinical outcomes by race by putting interaction terms between fRHI and race. The assumptions of the proportionality of hazards were evaluated using Schoenfeld residuals. Sensitivity analyses were performed to assess if the lag ...
Incidence of adverse clinical outcomes in patients with CD. For hospitalization and surgery, patients with events occurring during both first and second lines of biologic treatment were counted individually for each line of treatment. Overall totals count only the first event and therefore do not equa...
Conclusion The current findings suggest that the intermittent concurrent use of PPIs and clopidogrel is not associated with an increased risk of 18-month adverse clinical outcomes, and intermittent use of PPIs is associated with a lower rate of MACE and NACE.Peer...