may generate drug resistance by enhancing aerobic glycolysis in cancer cells (the “Warburg effect”) [86]. This metabolic pattern that promotes cancer cell development and invasiveness also induces enhanced extracellular acidity, whereas most drugs are weakly basic molecules. On the one hand, citrate...
Cardiovascular surgeryPostoperative fluid managementHeart failureRenal functionFluid management with diuretics is a key factor for postoperative management following cardiovascular surgery, and it is common to administer intermittent doses of diuretics and fluids in the early postoperative stage as primary ...