It has been demonstrated that a variety of cells are recruited to the TIME during the development of a tumor. The composition of the heterogeneous TIME is extremely complex, containing a variety of immunosuppressive cells, including tumor cells, cancer-associated fibroblasts (CAFs), vascular endotheli...
It has been demonstrated that a variety of cells are recruited to the TIME during the development of a tumor. The composition of the heterogeneous TIME is extremely complex, containing a variety of immunosuppressive cells, including tumor cells, cancer-associated fibroblasts (CAFs), vascular endotheli...
clinical outcomes and vaccines therefore need to elicit potent responses in these groups. This remains an important unmet medical need. Using influenza vaccines formulated for the elderly as an example, surmounting immunosenescence is achievable by modulation of the dose and/or adjuvant44,45. Applying...
The application of BNT162b2 and mRNA-1273 vaccines against SARS-CoV-2 infection has constituted a determinant resource to control the COVID-19 pandemic. Since the beginning of 2021, millions of doses have been administered in several countries of North and South America and Europe. M...
Traditional vaccines struggle to offer comprehensive protection because of mismatches with circulating viral strains. The development of a broad-spectrum vaccine is therefore crucial. This paper explores the potential of mRNA vaccine technology to address these challenges by providing a swift, adaptable, ...
Traditional vaccines struggle to offer comprehensive protection because of mismatches with circulating viral strains. The development of a broad-spectrum vaccine is therefore crucial. This paper explores the potential of mRNA vaccine technology to address these challenges by providing a swift, adaptable, ...
Traditional vaccines struggle to offer comprehensive protection because of mismatches with circulating viral strains. The development of a broad-spectrum vaccine is therefore crucial. This paper explores the potential of mRNA vaccine technology to address these challenges by providing a swift, adaptable, ...