ImmunotherapyImmune checkpoint inhibitorPredictive biomarkerCancer treatment has known a revolution with the emergence of immune checkpoint inhibitors. However, accurate theranostic biomarkers are lacking. In this review, we discuss different types of biomarkers currently under investigation. First, we focus ...
Immunotherapy has recently emerged as a treatment strategy which stimulates the human immune system to kill tumor cells. Tumor immunotherapy is based on immune editing, which enhances the antigenicity of tumor cells and increases the tumoricidal effect o
“While there are exciting examples of successful clinical strategies to mobilize the immune system to attack cancer cells, overall the results have not met the promise hoped for in tumor immunotherapy,” he said. “One reason for less than optimal results is that until recently there was insu...
Cancer cells evade immune responses by interacting with PD-1 and its ligand, PD-L1. Although monoclonal antibodies targeting this pathway have revolutionized oncology, their high production costs, poor oral bioavailability, and limited tumor penetration remain significant challenges. Small-molecule inhibitor...
This suggests a potential role for ferroptosis in tumor immunotherapy. Suppressing extracellular ATP functions by impeding the P2X7 receptor with 2’,3’-dialdehyde ATP diminishes the recruitment of antigen-presenting cells and anti-tumor immune responses. These DAMPs provoke immune reactions against ...
In an interview during the 2020 OncLive® State of the Science Summit™ on Lung Cancer, Natale, medical director, Clinical Lung Cancer Program, assistant clinical professor, Cedars-Sinai, expanded on the recent developments with immunotherapy in advanced NSCLC. OncLive: How is immunotherapy current...
We also focus on immunoediting and tumor neoantigens that can impact the efficacy of immunotherapies. Encouraging results have been observed with immunotherapeutic strategies; some clinical trials are reaching phase III. Significant progress has been made in unraveling the molecular and genetic ...
Immunotherapy has revolutionized cancer treatment and rejuvenated the field of tumor immunology. Several types of immunotherapy, including adoptive cell transfer (ACT) and immune checkpoint inhibitors (ICIs), have obtained durable clinical responses, but
Primer on Tumor Immunology and Cancer Immunotherapy Chapter 2 Cancer Immunotherapy: Are We There Yet? Chapter 3 Highlights and Summary of the 28th Annual Meeting of the Society for Immunotherapy of Cancer ··· (更多) 我来说两句 短评 ··· 热门 还没人写过短评呢 我要写书评 Advances ...
Depletion of regulatory T cells by anti-GITR mAb as a novel mechanism for cancer immunotherapy. Cancer Immunol. Immunother. 59, 1367–1377 (2010). Article CAS PubMed Google Scholar Simpson, T. R. et al. Fc-dependent depletion of tumor-infiltrating regulatory T cells co-defines the efficacy...