However, their variable degrees of resorption require repeated injections. To overcome these drawbacks, the author created a new injectable filler consisting of a mixture of hyaluronic acid filler and living autologous cells. In this chapter, the author's basic research and clinical experiences with ...
Nanotechnology has demonstrated immense potential in various fields, especially in biomedical field. Among these domains, the development of nanotechnology for diagnosing and treating vascular anomalies has garnered significant attention. Vascular anomalies refer to structural and functional anomalies within the...
Hyaluronic acid (HA) is a polymer can specifically bind 12 DOI: 10.55415/deep-2023-0006.v1 to CD44 overexpressed on inflamed synovial cells. In a study, PLGA modified with Luteinium-177 and HA was prepared for encapsulating MTX (177Lu-DOTA-HA- PLGA(MTX)). This 177Lu-DOTA-HA-PLGA(MTX...
In solid tumors, cancer cell nests are commonly encased within a dense fibrous matrix composed of high levels of collagen, fibronectin, and hyaluronic acid (HA). In addition, there is a diverse population of cancer-associated stromal cells (CASCs) that consists of mesenchymal stem cells (MSCs)...
Hydrogels can be classified into two types, i.e., natural hydrogels and synthetic hydrogels. Natural hydrogels, such as collagen, gelatin, hyaluronic acid (HA), chitosan, etc., always have good biocompatibility and biodegradability. However, their mechanical properties such as rigidity and stretchabil...
hyaluronic acid, agarose, cellulose, collagen, chondroitin sulfate, fibrin glue, gelatin, hyaluronic acid, and silk fibroin are generally used as scaffold materials. Limitations are there which also restricts the use of natural biomaterials for cartilage regeneration, such as the autoimmune response whic...
devised enzyme-responsive nanogels (EPNGs) cross-linked with cinnamyloxy groups in PEGylated hyaluronic acid, which are sensitive to hyaluronidase [66]. These EPNGs exhibit high loading efficiency and excellent stability in various biological media. However, they degrade rapidly within tumor cells that...
55 women with cutaneous ageing signs included in the Full Analysis Set (FAS) population blindly received intradermal micro-injections (50 脳 0.02 mL) of non-cross-linked HA filler with mannitol (Glytone 1, HA concentration: 14 mg/g) in one cheek and sa...
Hyaluronic acid (HA), a natural polysaccharide that binds explicitly to overexpressed CD44 in tumor tissues [66], has been widely used as a tumor-targeting agent due to its high compatibility and biodegradability. Mishra and colleagues formulated HA-coated liposomes by solvent injection. They loaded...
Natural polymers with biocompatibility and biodegradability, such as methylcellulose, hyaluronic acid, chitosan, and sodium alginate, have a wide range of applications in the biomedical field, including tissue engineering, antimicrobial applications, and drug delivery [58,59,60,61,62,63]. Some ...