In bone tissue engineering especially large bone defects we have yet to come up with a prefect solution. Issues we currently faced include: 1) angiogenesis; 2) mechano-induction; 3) resorption; and 4) remodelling. We need to develop strategies for bone regeneration to bone remodelling by ...
Recent Advances in Natural Derived Extracellular Matrix Materials in Bone Tissue Engineering The extracellular matrix materials or scaffolds play an important role in bone tissue engineering.Currently, The scaffold materials commonly used in bone t... C He - 《Progress in Biotechnology》 被引量: 10发...
Bone tissue engineering scaffold materials: Fundamentals, advances, and challenges Bone damage caused by trauma and tumors is a serious problem for human health, therefore, three-dimensional (3D) scaffolding materials that stimulate and p... C Xu,Z Liu,X Chen,... - 《Chinese Chemical Letters》...
Bone tissue engineering (BTE) aims to develop strategies to regenerate damaged or diseased bone using a combination of cells, growth factors, and biomaterials. This article highlights recent advances in BTE, with particular emphasis on the role of the biomaterials as scaffolding material to heal bone...
The complex biology behind the nano‐microstructure of bones and their repair mechanisms, which involve various types of chemical and biomechanical signaling amongst different cells, has set strong requirements for biomaterials to be used in bone tissue engineering. This review presents an overview of ...
Designing a graft to support bone and cartilage regeneration along with an interface is an immense engineering challenge. "In complex tissue repair, the biggest problem is not just regeneration, but the tissue-tissue integration with an interface," Nukavarapu says. ...
Recent advances in tissue engineering of cartilage, bone, and tendon Purpose of review: The research of tissue engineering includes the study of seed cells, biomaterials, and engineering of different tissue types in animals... W Liu,L Cui,Y Cao - 《Current Opinion in Orthopaedics》 被引量: ...
With the gradual demographic shift toward an aging and obese society, an increasing number of patients are suffering from bone and cartilage injuries. However, conventional therapies are hindered by the defects of materials, failing to adequately stimula
Table 2 The pathogenesis of bone defects Full size table 1.2 The importance of electrical stimulation and biomaterials in bone tissue engineering Over the past decades, bone tissue engineering, as a crucial element of regenerative medicine, has attracted considerable interest from academic and industrial...
Growth factors are a class of cytokines that stimulate cell growth and are widely used in clinical practice, such as wound healing, revascularization, bone repair, and nervous system disease. However, free growth factors have a short half-life and are instable in vivo. Therefore, the search of...