Nucleic acid aptamers exhibit great potential in diagnostic fields due to their high specificity, sensitivity, and multifunctionality. To fully utilize these features, specific detection technologies are required to characterize their interactions with target molecules. Current aptamer-based detection technologie...
Aptamers may be superior to antibodies in fields such as biomarker discovery, in vitro and in vivo diagnosis, precisely controlled drug release, and targeted therapy. However, aptamer commercialization has not occurred as quickly as expected, and few aptamer-based products have yet successfully ...
Aptamers may be superior to antibodies in fields such as biomarker discovery, in vitro and in vivo diagnosis, precisely controlled drug release, and targeted therapy. However, aptamer commercialization has not occurred as quickly as expected, and few aptamer-based products have yet successfully ...
cell-based DDSs, bacteria-based and phage-based DDSs) and hydrogels. Finally, we discuss the difficulties and prospective direction of bioorthogonal chemistry in drug delivery. We expect this review will help us understand the latest advances in the development of active targeting...
Grating-based technologies are very cheap, and they can be produced in bulk and provides the same results (Fan et al. 2008). Recently, aptamer-based SPR and bacterial detection sensors have been developed, which can detect targets in great sensitivity and complexity (Zhu et al. 2015; Vai...
W. Label-free electronic detection of thrombin in blood serum by using an aptamer-based sensor. Angew. Chem. Int. Ed. 44, 5456–5459 (2005). Article CAS Google Scholar Shin, S. R. et al. Aptamer-based microfluidic electrochemical biosensor for monitoring cell-secreted trace cardiac ...
Electrochemical, aptamer-based (E-AB) sensors already achieve continuous, real-time molecular measurements in vivo [52]. Specifically, the Plaxco group and others have demonstrated in vivo monitoring of over half a dozen small-molecule drug pharmacokinetic profiles in live rodents using E-ABs [53,...
. The use of microfluidic technologies for the capture of rare CTCs offers the advantage of fast, reliable sample separation, resulting in excellent yields and high specificity of target cells. Accordingly, several methods use microfluidic devices, such as Aptamer-based separation, peptide-based ...
and testing. This is a considerable reduction of the assay time required compared to previous resazurin-based biosensors, and a costless and easy-to-use AST methodology that can be easily implemented in a clinical scenario. As the developed biosensor was intended to be used for the detection of...
. The use of microfluidic technologies for the capture of rare CTCs offers the advantage of fast, reliable sample separation, resulting in excellent yields and high specificity of target cells. Accordingly, several methods use microfluidic devices, such as Aptamer-based separation, peptide-based ...