Colloids and Surfaces B: Biointerfaces Volume 159, 1 November 2017, Pages 62-77ReviewAdvances and challenges in stem cell culture Author links open overlay panelChristina McKee a b, G. Rasul Chaudhry a bShow more Add to Mendeley Share Cite https://doi.org/10.1016/j.colsurfb.2017.07.051Get...
Cell culturePhysical stimulation / PerfusionScaffoldBioreactors play an increasing role in tissue engineering鈥攖he generation of mammalian tissue equivalents in vitro. They can be applied for effective (stem) cell expansion, which is a crucial step concerning the fabrication of tissue engineering ...
Despite many reports of putative stem-cell-based treatments in genetic and degenerative disorders or severe injuries, the number of proven stem cell therapies has remained small. In this Review, we survey advances in stem cell research and describe the c
Stem cells are clonogenic cells capable of self-renewal and multi-lineage differentiation. Since the first isolation of dental pulp stem cells (DPSCs) in the early 2000s, stem cell research has continued to be an active topic in Endodontology. Over the last two decades, the literature has repo...
Figure 1. Recent advances in the engineering of a bioartificial pancreas: The figure represents (a) the current challenges of the clinical application of islet transplantation. Strategies to overcome these obstacles and create a bioartificial pancreas include (b) the use of alternative β-cell sources...
Diabetes mellitus is a significant global public health challenge, with a rising prevalence and associated morbidity and mortality. Cell therapy has evolved over time and holds great potential in diabetes treatment. In the present review, we discussed th
Future research should focus on elucidating germ cell differentiation mechanisms both in vivo and in vitro, identifying factors beyond RA that promote haploid formation, and ensuring genetic and epigenetic stability. These challenges remain central to future research in this field. Regulatory network of ...
However, CAR-T-cell therapy has not yet achieved comparable success in the management of aggressive T-cell malignancies. This article reviews the challenges of CAR-T-cell therapy in treating T-cell malignancies and summarizes the progress of preclinical and clinical studies in this area. We ...
their great potential, the therapeutic application of these bioactive factors for improving environment conducive to neural regeneration still encounters substantial challenges, such as the precise administration of the timing, dose and delivery routes, the likelihood of penetrating the BBB, and the ...
There are three pivotal challenges in the repair of tendon injuries: mechanical strength, regeneration, and graft integration. Firstly, since the tendons and enthesis (T/E) function as links and transmissions, they require not only excellent mechanical strength to support normal body locomotion, but...