Current applications of human pluripotent stem cells: possibilities and challenges Cell Transplant., 21 (2012), pp. 801-814 Google Scholar [20] S.S. Hung, S. Khan, C.Y. Lo, A.W. Hewitt, R.C. Wong Drug discovery using induced pluripotent stem cell models of neurodegenerative and ocular...
Future research should focus on elucidating germ cell differentiation mechanisms both in vivo and in vitro, identifying factors beyond RA that promote haploid formation, and ensuring genetic and epigenetic stability. These challenges remain central to future research in this field. Regulatory network of ...
Despite many reports of putative stem-cell-based treatments in genetic and degenerative disorders or severe injuries, the number of proven stem cell therapies has remained small. In this Review, we survey advances in stem cell research and describe the c
We also explore various methods for optimizing the function of MSC-EVs, including gene editing, modifying stem cell culture conditions and peptide modification. In addition, we discuss the therapeutic potentials of MSC-EVs, as well as the obstacles that currently impede their clinical utilization. ...
Xeno-free derivation and culture of human embryonic stem cells: current status, problems and challenges. Human embryonic stem cells (hESC) not only hold great promise for the treatment of degenerative diseases but also provide a valuable tool for developmental... Ting,Lei,Sandrine,... - 《Cell...
Cell culturePhysical stimulation / PerfusionScaffoldBioreactors play an increasing role in tissue engineering鈥攖he generation of mammalian tissue equivalents in vitro. They can be applied for effective (stem) cell expansion, which is a crucial step concerning the fabrication of tissue engineering ...
The average gene expression across sampled cells is obtained from bulk RNA-seq data, which masks cell heterogeneity [3]. Notably, in analyzing stem cells, circulating tumor cells, and other rare populations, the target cells may not account for a sufficient proportion of the bulk sample, due ...
Cell culture is one of the most core and fundamental techniques employed in the fields of biology and medicine. At present, although the two-dimensional cell culture method is commonly used in vitro, it is quite different from the cell growth microenvironment in vivo. In recent years, the limi...
Mesenchymal stem cells (MSCs) have emerged as the most extensively researched and applied stem cells in regenerative medicine [4]. Their therapeutic potential can be attributed to cell homing, promotion of cell differentiation, and secretion of bioactive factors [5, 6]. Actually, most of the ste...
Pluripotent stem cells in regenerative medicine: challenges and recent progress. After years of incremental progress, several recent studies have succeeded in deriving disease-relevant cell types from human pluripotent stem cell (hPSC) ... V Tabar,L Studer - 《Nature Reviews Genetics》 被引量: 323...