Immunotherapy (IO) has emerged as a promising therapeutic approach for LC, particularly in advanced-stage patients [1, 2]. Unlike traditional chemotherapy that directly targets and destroys cancer cells, IO harnesses the inherent capabilities of the patient’s immune system to suppress the growth of...
18 PFS alone, however, was not a valid surrogate for overall survival in trials comparing an anthracycline with a taxane for advanced breast cancer (R2=0·23).23 Few surrogacy assessments based on individual patient data have been done in lung cancer. In advanced NSCLC, treatment effects on ...
It was tested only after statistical significance for PFS, as assessed by the independent radiology center, was achieved, to control the overall type I error in the trial at the 1-sided significance level of .025. Overall survival was planned to be analyzed twice: at the time of the ...
Staining was performed only once in d and f. g Changes in tumor mutational burden (TMB) and tumor neoantigen burden (TNB) in patients P01 and P18 with MPR. h Changes in peripheral TCR clones in patient P18. Source data are provided as a Source Data file. Full size image Among them, ...
The results of chi-square test were presented in the Table 2. There was not correlation between patient characters and cluster results. The overall survival curve for the two groups are presented in Fig. 4. There was significant differences in overall survival (p = 0.032, Log-rank test)...
Apart from the patient who progressed during induction chemotherapy, no further patients underwent subsequent surgery. The remaining patients proceeded to concurrent radiochemotherapy (Fig. 1b). Metabolic responses with SUVmax decreases below 35% of the initial SUVmax were observed in 6 patients (see...
Thirty-three patients did not receive EBRT because radiotherapy was declined by the patient or postoperative histopathologic staging revealed Stage I disease and were excluded from further analysis. The data of the resulting 210 patients were evaluable. Initial investigation in all patients included ...
Accordingly, surgical bypass may be an alternative option for the treatment of long lesions in advanced PAD. Taking these results together, the optimal cure strategy (bypass surgery versus endovascular revascularization) demands a comprehensive understanding of anatomic configurations, patient conditions and...
(median PFS = 25.90 months; IQR: 17.00–50.20, log-rank testP = 0.00452); the latter belonging to the most favourable patient subgroup (Fig.1b). In order to assess RPV through its ability to predict survival or recurrence by specific landmark time points, we have compared ...
et al. Association between palliative care and patient and caregiver outcomes: a systematic review and meta-analysis. JAMA 316, 2104–2114 (2016). In this meta-analysis, palliative care interventions were associated with improvements in quality of life and symptom burden; there was no significant ...