Given the challenges in endogenous repair of damaged CMs, transplantation of ventricular-like pluripotent stem cell-derived CMs (PSC-CMs) has emerged as a promising therapeutic option for MI. Understanding the interaction mechanisms between these exogenous CMs and endogenous cardiac cells is essential to...
Given the challenges in endogenous repair of damaged CMs, transplantation of ventricular-like pluripotent stem cell-derived CMs (PSC-CMs) has emerged as a promising therapeutic option for MI. Understanding the interaction mechanisms between these exogenous CMs and endogenous cardiac cells is essential to...
Proteolysis-targeting chimeras (PROTACs) technology has garnered significant attention over the last 10 years, representing a burgeoning therapeutic approach with the potential to address pathogenic proteins that have historically posed challenges for traditional small-molecule inhibitors. PROTACs exploit the e...
ICD: Immunogenic cell death ROS: Reactive oxygen species TAAs: Tumor-associated antigens dsDNA: Double-stranded DNA DCs: Dendritic cells APCs: Antigen-presenting cells CTLs: Cytotoxic lymphocytes PRRs: Pattern recognition receptors TLR: Toll-like receptor MHC: Major histocompatibility compl...
Multifunctional materials: engineering applications and processing challenges Multifunctional materials are designed so as to meet specific requirements through tailored properties. Smart materials can be considered as multifunctiona... K Salonitis,J Pandremenos,J Paralikas,... - 《International Journal of...
Several potential directions are put forward for challenges that exist in the clinical applications. First, a deep investigation should be carried out regarding the immunomodulatory mechanisms of icaritin for advanced HCC treatment as well as the crosstalk between cancer cell death pathways. Second, ...
Schematic depiction of an in situ DC vaccine using chimeric cross-linked polymersomes (CCPS) as adjuvants combined with PDT and ICD for the treatment of MC38 colorectal cancer.aProcess of self-assembled nanoparticle formation.bImmune response in vivo after injection of CCPS/HPPH/DOX. Reprinted wit...
Study exclusion criteria were missing data on age or sex, histopathological codes indicating small cell lung cancer (i.e., International Classification of Diseases for Oncology [third edition; ICD-O-3] codes: 80413, 80423, 80433, 80443, 80453); a concomitant tumor within 5 years prior to ...
As clinicians, we know from personal experience and surveys that patients who are facing the challenges of advanced illness want to talk about their preferences and goals for care, and their clinical teams want to talk about the same issues, too. ...
Schematic depiction of an in situ DC vaccine using chimeric cross-linked polymersomes (CCPS) as adjuvants combined with PDT and ICD for the treatment of MC38 colorectal cancer.aProcess of self-assembled nanoparticle formation.bImmune response in vivo after injection of CCPS/HPPH/DOX. Reprinted wit...