Adult-onset Still’s disease (AOSD) is a systemic inflammatory disorder with an unknown cause characterized by high-spiking fever, lymphadenopathy, hepatosplenomegaly, hyperferritinemia, and leukocytosis. The clinical course can be divided into three significant patterns, each with a different prognosis...
Adult-onset Still’s disease (AOSD) was described by Eric Bywaters in 1970 as an inflammatory disease in young adults [1]. It is part of the spectrum of systemic-onset juvenile idiopathic arthritis (SJIA), which was described one hundred years ago by Sir John Still [2]. AOSD is a rare...
Adult-onset Still’s disease (AOSD) is a systemic inflammatory disease of unknown etiology. Recent studies have demonstrated that the hallmark of AOSD is a cytokine storm, which is characterized by the excessive production of interleukin (IL)-1, IL-6, IL-18, tumor necrosis factor-α (TNF-α...
Keywords: adult-onset Still’s disease;AOSD;autoinflammation;‘IL-1 driven’ disease;Th cells;CD8+ T cells;B cells;flow cytometry
adult-onset Still’s disease;myelodysplastic syndrome;SAID;USAID;VEXAS;azacytidine 1. Introduction Recently, the concept of autoinflammatory disorders keep evolving and an increasing number of new monogenic diseases are identified but numerous autoinflammatory diseases are still to be characterized. Systemic...