Adult-onset leukoencephalopathy with axonal spheroids and pigmented glia (ALSP) is a rare autosomal dominant disorder caused by mutations in the colony-stimulating factor 1 receptor (CSF1R) gene. As of 2022, more than 100 different CSF1R mutations were reported in patients with CSF1R-related ...
Mitochondrial encephalomyopathy with lactic acid and stroke-like episodes (MELAS) is a multisystem mitochondrial disorder that typically presents in childhood. We describe the follow-up of a patient who was diagnosed with late-onset MELAS at the age of 49. Her clinical course includes sensorineural ...
Adult-onset stuttering as a feature of schizophrenia: restoration of fluency with trifluoperazine Stuttering is generally known as a disorder rhat begins in c/i!dhood. But there has been growing number of reports of adult-onset stuttering (acquired stut... D Menkes 被引量: 0发表: 1991年...
The association between preterm birth and increased risk of adult-onset (defined as ≥16 years of age) schizophrenia is consistent with previous findings,11 but this is the first study to report an association between preterm birth and both depressive disorder and bipolar affective disorder. The ...
BDNF and COMT polymorphisms: relation to memory phenotypes in young adults with childhood-onset mood disorder. Neuromolecular Med. 2004;5:181–92. Article CAS PubMed Google Scholar Chen B, Dowlatshahi D, MacQueen GM, Wang JF, Young LT. Increased hippocampal BDNF immunoreactivity in subjects ...
The case for identifying biomarkers in chronic hydrocephalus of adult onset has arisen due to similar developments in other common causes of dementia and the increasing awareness of both the epidemiology of NPH [3,5] and its impact on the quality of life of elderly patients [94]. Ideally, use...
Major depressive disorder (MDD) was previously hypothesized to be a disease of monoamine deficiency in which low levels of monoamines in the synaptic cleft were believed to underlie depressive symptoms. More recently, however, there has been a paradigm s
For example, childhood-onset fluency disorder, also referred to as stuttering or stammering, is associated with a hyperdopaminergic tone in the striatum65,66,67. Dopaminergic antagonists have been shown to lessen stuttering and dopaminergic agonists are reported to transiently induce speech disturbances ...
Patients with bipolar disorder (BDP) are severely affected by the disorder and, as a result, are more susceptible to chronic stressors and interpersonal stress due to acute stressful life events [2]. Combined with cognitive impairments in attention, verbal processing, and verbal fluency, BD ...
Helekar et al.20 noted that stuttering in zebra finches can be learned from tutors, and thus this could be considered a developmentally learned disorder in them. The type of stuttering that zebra finches manifested in this study is developmental and neurogenic, as it was the result of both a...