The neural circuitry processing male sexual behavior is tightly regulated by testosterone and its neural metabolite estradiol. The present study evaluated the effects of adult exposure to low doses of nonylphenol (NP), a widespread environmental contamin
New neurons are continuously generated in the adult brain through a process called adult neurogenesis. This form of plasticity has been correlated with numerous behavioral and cognitive phenomena, but it remains unclear if and how adult-born neurons (abN
3b–e). Given MetR-longevity is marginal in males, the MetSO levels may not be the limiting factor for male lifespan. MsrA transcription is upregulated also in other tissues such as the brain or the thorax (muscle enriched), but not in the ovary (Supplementary Fig. 3f), suggesting that...
Total protein: 5.5–9.0 g/dL Cardiac enzymes Normal cardiac enzyme ranges include the following [1] : Creatine kinase: Female: 30–135 U/L; male: 55–170 U/L Creatine kinase MB (CKMB): ˂5% of total Troponin: ≤0.04 ng/mL Hormones Normal hormone ranges include the following [...
(G) Body composition of male and female mice 25 days post i.c.v. infusion onset is shown (n = 5–10). (H–J) Body weight changes in response to AraC infusion into the lateral (H, n = 5–12), third (I, n = 5–8), or fourth (J, n = 5–7) ventricle compared to aCSF...
Relatedly, compared to upper digestive tract sites, there was very high abundance of a specific multiple antibiotic resistance protein (K05595) and association with the pyruvate:ferredoxin oxidoreductase pathway, which, due to its role in converson of metronidazole to its active nitroso form, can ...
We found that a core mast cell transcriptional program was similarly expressed in all the three wave hematopoiesis-derived mast cells, including canonical mast-cell proteases, heparin-sulfate biosynthesis, and Mrgpr family of G-protein-coupled receptors (Figure 7A). Unsupervised clustering analysis ...
Chloride Intracellular Channel 4 (CLIC4) is one of seven members in the closely related CLIC protein family. CLIC4 is involved in multiple cellular processes including apoptosis, cellular differentiation, inflammation and endothelial tubulogenesis. Despite over a decade of research, no comprehensive in...
The hypothalamic–pituitary–gonadal axis is of relevance in many processes related to the development, maturation and ageing of the male. Through this axis, a cascade of coordinated activities is carried out leading to sustained testicular endocrine function, with gonadal testosterone production, as we...
positive and hence in G0 (quiescence),Lgr5+CBCcells in mice and NMRs that were unaccounted for by Ki67 staining did not show p27 positivity. The lack of Ki67 expression in these rodent cells may be reflective of the undetectable levels of this protein in G1 when Ki67 is continuously ...