Older adults with lower education are at greater risk for dementia. It is unclear which brain changes lead to these outcomes. Longitudinal imaging-based measures of brain structure and function were examined in adult individuals (baseline age, 45–86 yea
Quantification of event frequency was determined using peak detection algorithms in Igor Pro (using a smooth value of 200, and a box detection width of 5 points) and manual thresholding (using the larger of either 0.2 ΔF/F units or 1 SD above the non-signaling portion (defined as the ...