Heart injury has been characterized by the irreversible loss of cardiomyocytes comprising the contractile tissues of the heart and thus strategies enabling adult cardiomyocyte proliferation are highly desired for treating various heart diseases. Here, we test the ability of human induced pluripotent stem ...
Here, we show that corticotropin-releasing hormone (CRH), the major mediator of mammalian stress response and a key neuromodulator in the adult brain, is necessary for hippocampal neural stem cell (hiNSC) activity under physiological conditions. In particular, we demonstrate functionality of the ...
d.p.v with either of the 2 × 106 pfu or 2 × 107 pfu doses, we next wanted to investigate these CD8+T cells for their ability to rapidly respond to a secondary challenge and proliferate, since efficient clonal expansion is a key functionality of good memory ...
Thus, fission activity is specifically induced in SCs after muscle damage, but this activity is reduced in old age in both humans and mice. We then directly increased DRP1 expression in aged SCs using a lentiviral vector (LV) expressing DRP1 under a phosphoglycerate kinase (PGK) promotor (LV-...
These previously described associations have important clinical implications in our study population, highlighting the importance of increasing physical activity levels [59] in the institutionalized elderly population to reduce the risk of sarcopenia and improve functionality and independence. 4.4. Need to ...
In reality, the stark variation in the underlying nutrient and lipid availability, pH and water activity (aw) and the resultant commensal microbiome, means the skin microbiome could be considered to be a collection of discrete microbiomes, each with their own unique characteristics [15,25]. The...
Interestingly, however, recent cryo-EM studies of the yeast OXR1 homologue (Oxr1p) point towards a disruptive rather than facilitatory role for the protein with respect to v-ATPase activity [46]. Data from loss-of-function OXR1 patient fibroblasts suggest enhanced lysosomal biogenesis [7,49],...
Actin network architecture can determine myosin motor activity. Science 2012, 336, 1310–1314. [CrossRef] [PubMed] 34. Stewart, R.M.; Zubek, A.E.; Rosowski, K.A.; Schreiner, S.M.; Horsley, V.; King, M.C. Nuclear–cytoskeletal linkages facilitate cross talk between the nucleus and...
In contrast, plants overexpressing a non-cleavable miR156-target mimic (MIM156), which reduces the activity of miR156, did not produce any juvenile leaves after germination [10]. These data strongly suggest that miR156 acts as a key regulator for vegetative phase change with decreased expression...
Two of the networked proteins, protein/nucleic acid deglycase DJ-1 (PARK7) and peroxiredoxin-5 mitochondrial (PRDX5), were indicated as involved in peroxiredoxin activity. Analysis of the supernatant of thawed semen proteins differentiating young and adult bulls showed that four proteins could be ...