External beam radiotherapy (EBRT) is a well-established definitive therapeutic approach for clinically localized prostate cancer (CLPCa). Although CLPCa had been mainly treated with EBRT alone, androgen deprivation therapy (ADT) has been shown to improve not only biochemical control but also survival...
One randomized trial has shown a survival advantage for men treated with immediate adjuvant (adj) ADT compared treatment at onset of clinical metastases. However, benefit of immediate therapy is less clear in the PSA era when ADT can initiated at the time of biochemical relapse. Methods: We ...
达罗他胺联合ADT二联起始治疗mHSPC,为高+低瘤负荷患者带来长生存获益 我国转移性激素敏感性前列腺癌(mHSPC)患者基线状态复杂,PSA达标率仅约50%[1,2],5年生存率仅约35%[3],严重威胁我国老年男性健康。近年来,达罗他胺等新型雄激...
发表了题为“Real-world retrospective study of prostate-specific antigen and safety assessment with darolutamide plus androgen deprivation therapy for metastasis hormone-sensitive prostate cancer”的论文[2],旨在从真实世界角度,回顾性...
[2] Guo Z, et al. Eur J Med Res. Docetaxel chemotherapy plus androgen-deprivation therapy in high-volume disease metastatic hormone-sensitive prostate cancer in Chinese patients: an efficacy and safety analysis. 2022;27(1):148. [3] 王国民, 等. 1673例前列腺癌的诊治和预后——上海单中心10年...
Androgen-deprivation therapy (ADT) is a fundamental element of treatment for nonlocalized prostate cancer and for patients with high-risk disease who are not candidates for radical treatment. ADT has been linked to metabolic syndrome, which involves changes in me...
Given that androgen-deprivation therapy (ADT) is one of the mainstays of treatment for advanced prostate cancer, we investigated the development of biochem...vekri
104 Orgasm in Men on Androgen Deprivation Therapy (ADT) for Prostate Cancerdoi:10.1016/j.jsxm.2016.02.111Mazzola, C.Teloken, P.E.Matsuhsita, K.Nelson, C.J.Mulhall, J.P.Elsevier Inc.Journal of Sexual Medicine
However, responses in castration-resistant prostate cancer remain relatively rare—potentially due to low baseline levels of infiltration. Using an immunocompetent cMyc-driven model (Myc-CaP), we sought to understand the immune infiltrate induced by androgen deprivation therapy (ADT) and to leverage ...
Methods: STAND evaluates optimal sequencing of sip-T and ADT in men with BRPC at high risk for metastases. Men (N = 68) were randomized 1:1 to Arm 1: sip-T followed by ADT (2 wks after 3rd infusion) or Arm 2: ADT (3 mo lead-in) followed by sip-T. All men had 3 doses ...