After adrenaline, regardless of route of administration, pharmacokinetic parameters were significantly higher ( P < 0.05) than after placebo RDSTs administration (reflecting endogenous adrenaline levels). Conclusion Epi-MC RDSTs facilitated a twofold increase in Epi absorption and a 50% reduction ...
ROUTE OF EXPOSURE : Administration onto the skin SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 62 mg/kg TOXIC EFFECTS : Behavioral - somnolence (general depressed activity) Behavioral - convulsions or effect on seizure threshold Behavioral - excitement TYPE OF TEST : LDLo - Lowest pub...
Intramuscular, intravenous, and other routes comprised 82%, 13%, and 5% of all adrenaline administration in our study, respectively. All major guidelines indicate intra- muscular adrenaline as a first line treatment of anaphylaxis because of safety problem compared to intravenous route. Despite 2 ...
Background: Tracheal drug administration is a route for drug delivery during cardiopulmonary resuscitation when intravenous access is not immediately available. However, tracheal adrenaline (epinephrine) injection has been recently shown to be associated with detrimental decrease in blood pressure. This was...
We otolaryngologists think so because we administered adrenaline to the vocal folds for hemostasis after intracordal injection under local anesthesia, but have had few cases of vital changes. We hypothesized that examining vital signs before and after adrenaline administration for hemostasis would help...
The heart rate decreased from 4 to 15 minutes postinjection in group V. In contrast, Groups A and AV had increases in heart rate. In Group A, the arterial pressure decreased initially after adrenaline administration and then gradually increased. Group V demonstrated an increase in arterial ...