Patients taking physiological replacement doses of corticosteroids for either primary or secondary adrenal insufficiency are at significant risk of adrenal crisis and must be given stress doses of hydrocortisone
Adrenal insufficiency (AI) is a clinical condition which is caused by a failure of cortisol synthesis in, and secretion from, the adrenal cortex [1]. AI may occur secondary to pathology of the adrenal gland (primary adrenal insufficiency, PAI), hypothalamic or pituitary ...
Adrenal crisis may result from an acute exacerbation of chronic insufficiency,[10]usually caused by sepsis or surgical stress. Acute adrenal insufficiency also can be caused by adrenal hemorrhage (eg, usually septicemia-induced Waterhouse-Friderichsen syndrome [fulminant meningococcemia]) and anticoagula...
An adrenal crisis , a potentially life-threatening disorder, arises from an acute deficiency of the adrenal hormone cortisol, a glucocorticoid. Adrenal crisis should not be confused with chronic, stable adrenal insufficiency, such as Addison disease (primary adrenal insufficiency). [1] In 1855, Th...
and the presentation and treatment of adrenal crisis. Additionally we discuss some more controversial aspects of adrenal function in critical illness: the concept of “critical illness-related corticosteroid insufficiency”, and the role of plasma cortisol measurements and the short Synacthen test in in...
Adrenal insufficiency and other adrenal oncologic emergencies Emerg. Med. Clin. N. Am., 27 (2) (2009), pp. 271-282 View PDFView articleView in ScopusGoogle Scholar [4] A.W. Kung, K.K. Pun, K. Lam, C. Wang, C.Y. Leung Addisonian crisis as presenting feature in malignancies Cance...
Prevalence of Adrenal Insufficiency Following Systemic Glucocorticoid Therapy in Infants With Hemangiomas Lomenick JP, Reifschneider KL, Lucky AW, et al Arch Dermatol. 2009;145:262-266 Summary Hemangiomas of infancy (HOI) are sporadically occurring tumors of vascular endothelium that typically present du...
status, even after adjusting for age, sex, and type of adrenal insufficiency.25This study also demonstrated that patients with adrenal insufficiency, especially those with SAI andGIAI, encountered significant delays in proper treatment of adrenal crisis in theemergency department, and they often ...
Why would a pt suspected of adrenal crisis need a CT head? to assess the pituitary gland How do you tx adrenal crisis? 1. NS and glucocorticoid replacement 2. steroids If pt is hypoglycemic, which fluids would you give? D5 in NS If pt does NOT have a hx of adrenal insufficiency, whi...
Data show that approximately 6 to 8% of patients suf- fering from adrenal insufficiency manifest at least one episode of acute adrenal crisis, especially during coex- isting illnesses that tend to precipitate the crisis, which could be even fatal if not adequately treated [14]. Moreo- ver,...