In autosomal dominant polycystic kidney disease (ADPKD) multiple bilateral renal cysts gradually enlarge, leading to a decline in renal function. Transepithelial chloride secretion through cystic fibrosis transmembrane conductance regulator (CFTR) and TMEM16A () are known to drive cyst enlargement. Here ...
Mutations to PKD1 and PKD2 are associated with autosomal dominant polycystic kidney disease (ADPKD). The absence of apparent PKD1/PKD2 linkage in five published European or North American families with ADPKD suggested a third locus, designated PKD3. Here we re-evaluated these families by updating cl...
About this article Cite this article Left ventricular mass is increased in children with ADPKD who have borderline hypertension.Nat Rev Nephrol4, 645–646 (2008). https://doi.org/10.1038/ncpneph0959 Issue DateDecember 2008 DOIhttps://doi.org/10.1038/ncpneph0959 ...
Sonography is not a suitable method for assessing short-term disease progression in ADPKDRecently published results from the Consortium of Renal Imaging Studies in Polycystic Kidney Disease (CRISP) indicate that ultrasonography lacks the accuracy and precision needed to follow short-term progression in ...
Statement of Significance: Autosomal dominant polycystic kidney disease (ADPKD) is a ciliopathic condition resulting from mutations in the polycystin genes, PKD1 and PKD2.This disease manifests as prominent fluid-filled renal cysts and other extrarenal abnormalities.Zebrafish models of ADPKD develop the...
Visceral Adiposity Is Strongly Associated With Kidney Growth in Early-Stage Autosomal Dominant Polycystic Kidney Disease (ADPKD)doi:10.1681/ASN.20223311S1155cKristen L. NowakUniversity of Colorado - Anschutz Medical Campus, Aurora, COCortney Steele...
Glis3 Is a Modifier of Cyst Progression in Autosomal Dominant Polycystic Kidney Disease (ADPKD)doi:10.1681/ASN.2024x2zerq4tZemeng WeiXin TianMichael RehmanKe DongYiqiang CaiAdrian CordidoStefan SomloAmerican Society of NephrologyJournal of the American Society of Nephrology...
2001. From the Cover: Polycystin-2, the protein mutated in autosomal dominant polycystic kidney disease (ADPKD), is a Ca2+~permeable nonselective cation channel. PNAS 98:1 182-1 187.Gonzalez-Perret, S., Kim, K., Ibarra, C., Damiano, A.E., Zotta, E., Batelli, M., Harris, P.C...
Therefore, urine volume after initiating tolvaptan in patients with ADPKD is influenced mainly by the degree of renal function. There might also be a contribution of urinary solute load but it can not be studied using total solute excretion due to collinearity. We propose that the urinary solute...
González-Perrett S, Kim K, Ibarra C, Damiano AE, Zotta E, Batelli M, Harris PC, Reisin IL, Arnaout MA, Cantiello HF (2001) Polycystin-2, the protein mutated in autosomal dominant polycystic kidney disease (ADPKD), is a Ca 2+ -permeable nonselective cation channel. Proc Natl Acad ...