To capture the structure of proteasome in the presence of ADP-AlFx (denoted as “proteasome-ADP-AlFx”) at high resolution, we collected 13 871 micrographs of the yeast single-capped 26S proteasome in complex with ADP-AlFx. Data collection was carried out on a Titan Krios transmission elect...
Moreover, alpha-chaperonin incubated with ATP and AlFx or BeFx adopted a symmetric closed conformation, and its functional turnover was inhibited. These forms are supposed to be intermediates during the reaction cycle of group II chaperonins....
J. et al. X-ray structures of the myosin motor domain of Dictyostelium discoideum complexed with MgADP·BeFx and MgADP·AlF−4 . Biochemistry 34, 8960–8972 (1995). Article CAS Google Scholar Sondek, J., Lambright, D. G., Noel, J. P., Hamm, H. E. & Sigler, P. B. GTPase...
This observation correlates well with the AlFx species reported in published X-ray structures. Furthermore, a high-resolution study of UMP/CMP-kinase complexed with ADP and aluminofluoride revealed AlF4 bound at the active site of the structure determined at pH 4.5, and AlF3 bound in the ...
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et al. Apoptosis-inducing factor mediates poly(ADP-ribose) (PAR) polymer-induced cell death. Proc. Natl Acad. Sci. USA 103, 18314–18319 (2006). 16. Cuzzocrea, S. et al. Role of poly(ADP-ribose) glycohydrolase in the development of inflammatory bowel disease in mice. Free Radic. ...
The H2A histone family member X (usually abbreviated as H2AX) is a type of histone protein from the H2A family encoded by the H2AFX gene. An important phosphorylated form is γH2AX (140S), which forms when DSBs appear. H2AX becomes phosphorylated on serine 139 and then called γH2AX, as ...