DNA damage shuts down genome-wide transcription to prevent transcriptional mutagenesis and to initiate repair signalling, but the mechanism to stall elongating RNA polymerase II (Pol II) is not fully understood. Central to the DNA damage response,
& Feany, M. B. PARP inhibitors and Parkinson’s disease. N. Engl. J. Med. 380, 492–494 (2019). PubMed Google Scholar Choi, S. K. et al. Poly(ADP-ribose) polymerase 1 inhibition improves coronary arteriole function in type 2 diabetes mellitus. Hypertension 59, 1060–1068 (2012)...
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本发明提供用于治疗或预防能够通过抑制聚(ADP核糖)聚合酶(PARP)得到改善的病症的化合物(参见例如,Nature Review DrugDiscovery(2005)4421-440)。 因此,本发明提供一种用于制造药物的式I化合物,该药物用于治疗或预防能够通过抑制聚(ADP核糖)聚合酶(PARP)得到改善的病症。
2003, Annual Review of Physiology The oligomeric nature of Na/K-transport ATPase 2001, Journal of Biochemistry The complex ATP-Fe<sup>2+</sup> serves as a specific affinity cleavage reagent in ATP-Mg<sup>2+</sup> sites of Na,K-ATPase: Altered ligation of Fe<sup>2+</sup> (Mg<sup>...
and F.B.; writing—review and editing, A.E. and F.B.; funding acquisition, F.B. All authors have read and agreed to the published version of the manuscript. Funding This research was funded by PAPIIT UNAM, grant IN209421. Institutional Review Board Statement Not applicable. Informed ...
and X.C.; Project administration, X.C.; Supervision, X.C.; Writing– original draft, Q.Y., S.Y., B.M. and X.C.; Writing–review & editing, X.C. All authors have read and agreed to the published version of the manuscript. Funding: The research was supported by the National ...
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最近被分类到贝利不动杆菌ADP1的不动杆菌ADP1是具有利用宽范围碳源的能力的土壤细菌(Youngetal(2005)AnnualReviewofMicrobiology59)。不动4干菌和々I单月包菌属于同一属(genus),贝利不动杆菌ADP1的基因组大小是3.6Mb,并且具有的GC含量是40%,与之相比假单胞菌具有大约5.4Mb的基因组和平均62%的GC含量。对于ADPWH...