sites (Figure 2A). Additionally, our AI-ETD profiling of the ADP-ribosylome from limited input revealed 1,800 ADPr target proteins (Table S3), corresponding to 84% of identifications from the largest study to date (Hendriks et al., 2019). Over half of the ADPr target proteins were modif...
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RNAs (sgRNAs) targeting exon 2 of human PARP10 gene (forward: 5’-caccgAAAACCGCCGACGCTCTGGA-3’ and reverse: 5’-aaacTCCAGAGCGTCGGCGGTTTTc-3’) were designed using the CRISPick tool (https://portals.broadinstitute.org/gpp/public/analysis-tools/sgrna-design accessed on 21 September 2020)...
Received: 10 July 2020; Accepted: 10 September 2020; Published: 16 September 2020 Abstract: Y-box-binding protein 1 (YB-1) is a multifunctional positively charged protein that interacts with DNA or RNA and poly(ADP-ribose) (PAR). YB-1 is poly(ADP-ribosyl)ated and stimulates poly(ADP-...