Wilhns, B. and Boustani, A. (1988)Comparison of pre- prandial administration of regular insulin with adminis- tration of NPH insulin at bed time and of conventional insulin therapy in combination therapy with in- sulin/sulfonyhuea in type-11diabetes. In: W. Bachmann, N. Lots and H. ...
Circulating levels of immunoreactive insulin were measured in healthy subjects and newly diagnosed diabetic patients after the injection of regular and NPH (isophane) insulin. The peak concentration of serum insulin was 26.2±2.9 μU/ml 60 min following the administration of 10 U s.c. regular ins...
What is described are pharmaceutical compositions, formulations, and uses thereof, for medicaments for intranasal delivery of insulin to a patient, comprising an aqueous mixture of human insulin, a solubilizing agent, and a surface active agent, wherein the human insulin may be rapid actin insulin....
Three days after confirmation of diabetes mellitus, the dogs were orally administered C. colocynthis capsules twice daily for 8days. The other diabetic group was injected with a combination of neutral protamine Hagedorn (NPH) [insulin isophane (NPH)鈥揌uman-Exir] and regular crystalline insulin ...
Intersubject variation in the disposition kinetics was small with half-lives of 0.52 ± 0.05 h and total body clearances of 16.21 ± 2.08ml min-1 kg-1. Calculated insulin plasma secretion rates in the canines were 14.4 ± 3.3 mUh-1 kg-1. Following SC injection of regular insulin, the ...
Cost-Effectiveness of Pen Devices For Nph Insulin Administration Compared With Syringe And Vial In Adult Patients With Diabetes Mellitus In Colombia.doi:10.1016/j.jval.2015.09.685LasalviaBarahonaRomeroGilCasta?eda-CardonaJ GBayonaJ JTrianaLaserna...
Figure 2. Characteristics of mice with regular diet (RD), or high-glucose diet (HGD), or high-fructose diet (HFrD) with or without Lactiplantibacillus plantarum (Lp) are demonstrated as determined by fasting blood profile (glucose, fructose, and insulin) (A–C), oral glucose tolerance tes...
Keywords: intranasal drug administration; nose-to-brain drug delivery; drug delivery system; insulin delivery to brain; olfactory nerve route; nanodelivery 1. Introduction The blood–brain barrier (BBB) pharmacokinetically blocks the entry of therapeutic agents into the brain. This impermeability ...