Trials in the early adjuvant setting have revealed that AIs are generally well tolerated: side effects are predictable and manageable. Although further studies are required to determine the optimum treatment strategy and duration of AI therapy, the third-generation AIs are proving highly effective ...
Ipilimumab Dosing Significance in Adjuvant Setting EP: 6.COMBI-i Trial Data Updates EP: 7.Triple Therapy for the Management of Melanoma EP: 8.Immune Checkpoint Inhibition in Stage IV Melanoma Transcript: Axel Hauschild, MD:If you don’t have a good explanation, may I ask you a question,...
Summary The available trials testing the efficacy of the AIs in the adjuvant setting all demonstrate the activity of the AIs in the adjuvant treatment of receptor-positive or unknown receptor status breast cancer in postmenopausal women. Two of these trials demonstrate superior activity compared with ...
Define adjuvant. adjuvant synonyms, adjuvant pronunciation, adjuvant translation, English dictionary definition of adjuvant. n. 1. A treatment that enhances an existing medical regimen, as a pharmacological agent added to a drug to increase or aid its ef
Oophorectomy has been shown to be of benefit in the adjuvant setting for premenopausal women with hormone- receptor-positive breast cancer.[ 24,25] There are now several options for ovarian suppression or ablation. Permanent ablation can be achieved surgically or with irradiation, and temporary ...
“Immunotherapy in the adjuvant setting has a good future. In the presence of [positive] data for neoadjuvant therapy, there is no reason to believe that [therapies] in the adjuvant setting will not work,” Hauschild said. In an interview withOncLive, Hauschild elucidated the evolving landscape...
In the case of doxorubicin, for example, it took as long as 20 years to proceed from the first single-agent phase I study in the salvage setting to an adjuvant phase III trial of anthracycline-containing combination chemotherapy. However, in view of the increasing number of new drugs in ...
Therefore, it is reasonable that pemetrexed be investigated in the adjuvant setting. This review collates data from January 2000 through August 2012 on the use of pemetrexed-platinum regimens in the adjuvant setting either alone or in combination with targeted agents. To date, more than 1000 ...
With significant level 1 data, osimertinib (Tagrisso) has been established as a preferred treatment option in the adjuvant setting for patients with EGFR-positive non–small cell lung cancer (NSCLC) and in the frontline setting for those with EGFR-positive advanced...
Adjuvant medical therapy1PTRASTUZUMAB IN THE ADJUVANT SETTING: RETROSPECTIVE STUDY2PCOMPLIANCE IN ADJUVANT BREAST CANCER THERAPY3PWHICH IS YOUR CHOICE? NEOADJUVANT DOXORUBICIN AND DOXETAXEL (AD) VERSUS DOXORUBICIN, CYCLOPHOSPHAMIDE AND PACLITAXEL (ACT) IN LOCALLY ADVANCED BREAST CANCER4PANALY...