q-value是FDR的另一种表达方式，通过优化p值分布来计算，可以提供更准确的假阳性和假阴性预测。以代谢组学为例，q-value分析可以更准确地估计在大量假设检验中，哪些显著结果可能是误报。表1中显示，化合物A的p值虽然小，但q值较大，提示其显著性有较高的假阳性的可能性。在选择阈值时，应考虑q值而...
q-value是利用优化的FDR方法找到调整后的p值。通过利用p值分布的特征生成q值列表来优化FDR的方法。再来举个具体例子来理解q-value。在代谢组学实验中,我们通常会测试数百或数千个化合物变量。这些测试中的每一个都会产生一个p值。p值采用0到1之间的值,我们可以创建直方图来了解p值在0到1之间的分布情况。一些典...
terminology "q-value" for a quantity estimates his definition of FDR. He implemented q-value estimation procedures in an R package called qvalue. So, strictly speaking, the q-value and the FDR adjusted p-value are similar but not quite the same. However the terms q-value and FDR adjusted...
The critical value is determined based on the desired false discovery rate (FDR) control. Here are the steps involved in calculating adjusted p-values using the Benjamini-Hochberg procedure: Sort the p-values in ascending order. Assign a rank or position (denoted as “i”) to each p-value...
terminology "q-value" for a quantity estimates his definition of FDR. He implemented q-value estimation procedures in an R package called qvalue.So, strictly speaking, the q-value and the FDR adjusted p-value are similar but not quite the same. However the terms ...