However, we found there was no difference in either NE content or NETO in these tissues between WT and TRKC + /− mice after a 16-hour cold exposure (Supplementary Fig. 16c, d). Thus, our data strongly support the importance of adipose tissue-derived NT-3 and TRKC in the ...
Adipose tissue is a highly metabolic organ that regulates energy balance in the body. In the context of cancer, adipose tissue can be found in close proximity to tumors and tumors can grow in the vicinity of or metastasize to adipose tissue, which helps to form a unique tumor microenvironment...
ERK: extracellular regulated kinase; JNK: Jun-kinase; hAMSCs: human adipose tissue-derived mesenchymal stem cells; AIM: adipogenic induction medium. To determine whether PG could inhibit adipogenesis via the ERK or p38 signaling pathway, we used the specific mitogen-activated protein kinase (MEK) ...
The effects of ECS activation on inflammatory responses are complex and vary depending on the tissue, eCBs, and the type of receptor. For example, AEA has anti-inflammatory effects, including the inhibition of chemoattractant cytokines secretion, especially those released at the early stages of the ...
Substrate at a stiffness of 30 kPa, which mimics the stiffness of native fibrotic cardiac tissue, was found to induce cardiac myofibroblast differentiation to create in vitro cardiac fibrosis model. Conditioned medium of hMSCs was applied to the model to determine its role and inhibitory mechanism...
in cell migration rate in comparison to untreated cells (Fig.1F). These results demonstrate that the MDA-MB-231 derived-EVs can trigger a pro-migratory adaptive response in hADMSC, confirming a potential bidirectional chemoattractive movement from adipose tissue cells towards the tumor ...
Apart from the de novo synthesis, excess adipose tissue supplies TME of breast cancer and leukemia cells with free fatty acids, adipokines, and immune cells to stimulate the cancer cells to proliferate and metastasize to distant organs and aid in the signaling process of many biological pathways,...
Keywords: STAT3; mitochondrial STAT3; adipose tissue; cancer; oncogenesis; inflammation; adipocytokine signalling 1. Introduction The remodelling of cancer cells in a tumour environment is a need to ensure survival and proliferation in response to extrinsic and intrinsic signals. The interaction of ...
Mesenchymal stromal cells (MSCs) represent a heterogeneous population of cells involved in tissue regeneration and homeostasis. They were initially identified in the bone marrow; however, further research has shown that they might be isolated from many fetal, neonatal, and adult tissues [1]. In an...
nutrients Article 3,5-Diiodo-L-Thyronine Exerts Metabolically Favorable Effects on Visceral Adipose Tissue of Rats Receiving a High-Fat Diet Elena Silvestri 1,†, Rosalba Senese 2,†, Federica Cioffi 1, Rita De Matteis 3, Davide Lattanzi 3, Assunta Lombardi 4, Antonia Giacco 1, Anna ...