White adipose tissue is composed of mature adipocytes, precursors (preadipocytes), endothelial cells, macrophages, and other immune cells. The phenotype, amount, and biology of each adipose tissue component are profoundly altered in human obesity. Low-grade inflammation both at the local and systemic...
09 celladipose tissue macrophage-derived exosomal mirnas can mod 09脂肪组织巨噬细胞衍生外泌体可以调节体内体外胰岛素.pdf,Please cite this article in press as: Ying et al., Adipose Tissue Macrophage-Derived Exosomal miRNAs Can Modulate In Vivo and In Vitro
Tissue blocks from all depots were labeled either for histology or for the analysis of cells in suspension. All animal handling was done following both national and institutional guidelines of the Animal Care and Use Committee of the University of Navarra. Sample preparation and imaging Sample ...
UVB radiation induces oxidative stress, DNA damage, and inflammation, leading to skin wrinkling, compromised barrier function, and an increased risk of carcinogenesis. Addressing or preventing photoaging may offer a promising therapeutic avenue for these
In terms of the anatomical distribution of adipose tissue, SAT and greater omental adipose tissue (OAT) are white adipose tissue (WAT), and perirenal adipose tissue (PAT) is brown adipose tissue (BAT) [2]. In addition to playing an essential role in energy homeostasis, WAT also acts as ...
Brown adipocytes can convert stored fat into heat energy through mitochondrial uncoupling protein 1 (UCP1), which targets brown adipose tissue (BAT) activity. The mitochondria are enriched in brown adipocytes, which regulate energy metabolism in response to the external environment and hormones in ...
5d). Gpat3 is responsible for ~80% of the enzyme activity in WAT and is expressed during adipogenesis37; conversely, the male-dominant isoform Gpat4 is predominant in brown adipose tissue (BAT)37. Agpat, an enzyme family involved in glycerolipid and phospholipid synthesis, also displayed ...
reuteri, propionate, and beige fat tissue in the anti-obesity action of CQA through the regulation of thermogenesis. These findings provide mechanistic insights into the therapeutic use of herbal ingredients with poor bioavailability via their interaction with the gut microbiota. Video Abstract...
Last, we obtained serial autopsy sections of coronary arteries with adjacent perivascular fat from HIV-positive and HIV-negative donors to confirm the presence of immune cells in adipose tissue by histology, and ensure that these cells did not represent contamination from blood. CD4+ and CX3CR1+...
However adipose derived tissue, whether stromal vascular fraction (SVF) or adipose-derived stem cells (ADSCs), has from 100 up to 500 times more stem cells than the bone marrow [9]. Moreover, lipoaspirates are easier to obtain with decreased incidence of complications and morbidity [10]. ...