Adipose-derived stromal/stem cells (ASCs) and mature adipocytes are a normal part of the breast tissue composition and not only contribute to normal breast physiology but also play a significant role in breast cancer pathophysiology. Given the recognized pro-tumorigenic role of adipoc...
Among the many different cell types present in mammary tissue, the most abundant that surround breast cancer cells are those that make up adipose tissue, mainly mature adipocytes and their precursor cells, preadipocytes. An important number of primary breast tumors are originated by the ...
Introduction/aims Obesity, an excess accumulation of adipose tissue occurring in mammalians when caloric intake exceeds energy expenditure, is associated with an increased incidence, morbidity and mortality from several types of neoplastic diseases including postmenopausal breast cancer. Methods and results ...
Intraopertive radiation therapy for breast cancer Because breast irradiation routinely produces a desmoplastic tissue response in the breast, there seems to be an opportunity here to address local recurrences... HW Merrick,E Hager,RR Dobelbower - 《Surgical Oncology Clinics of North America》 被引...
ADSCs primarily exist in fat tissue, as well as the breast cancer microenvironment. Besides the resident ADSCs and those inoculated by white adipose tissue grafting, ADSCs could also be recruited from the blood to tumor center. The investigators label adipose tissue with GFP and found that ADS...
Recent studies have shown that cells from adipose tissue are capable of trafficking to tumors, thus enabling paracrine action of adipokines from within the tumor microenvironment. Increased tumor vascularization, immune system suppression and direct effects on malignant cell survival and proliferation have ...
Studying Adipose Tissue in the Breast Tumor Microenvironment In Vitro : Progress and OpportunitiesAdipocyteBreast cancer3D cultureMicroenvironmentPhenotypic assayBackground: The breast cancer microenvironment contains a variety of stromal cells that are widely implicated in worse patient outcomes. While many ...
The association between the levels of various fatty acids in adipose breast tissue and the emergence of visceral metastases was prospectively studied in a cohort of 121 patients with an initially localised breast cancer. Adipose breast tissue was obtaine
ADSCs primarily exist in fat tissue, as well as the breast cancer microenvironment. Besides the resident ADSCs and those inoculated by white adipose tissue grafting, ADSCs could also be recruited from the blood to tumor center. The investigators label adipose tissue with GFP and found that ADS...
Crown-like structures of the breast (CLS-B), defined by the clustering of macrophages (identified using CD68 immunohistochemical staining) to surround a dying adipocyte, are a sign of adipose-tissue inflammation. In human cohorts, CLS-B positively correl