With respect to the transcriptional regulation of renal adiponectin, we analyzed the renal adiponectin expression in Six2 Cre/ PPARγflox/flox (renal PPARγ KO) mice. PPARγ is the master regulator for the differentiation of adipocytes and governs the expression of adiponectin in adipocytes. Renal...
adipocyteceiling culturededifferentiationliposecretionDFATCre-recombinaseDFAT cells represent an attractive source of stem cells in tissue engineering and in the potential treatment of several clinical conditions. Our objective was to determine whether DFAT cells originate from mature adipocytes and address ...
Adiponectin is a circulating hormone predominantly se- creted from adipocytes. Unlike many other adipokines that are up-regulated in obesity, such as TNFα, IL-6, leptin and resistin, the circulating levels of adiponectin are inversely as- sociated with obesity-related disorders. Many in vitro ...
These designators in the figure represent the binding sites in the adiponectin gene sequence, including hexanucleotide repeat expansions (HRE), E-Box, peroxisome proliferator response element (PPRE), LRH-RE, CRE, enhancer, and so forth. The specific details of the mechanisms are described in ...
Early studies using genetically engineered 3T3 cells suggested that Insr function is required for adipogenesis, although prolonged passage of cells may have reduced the differentiative capacity of the cells12. Recent studies using cre-mediated gene deletion in murine primary brown preadipocytes have ...
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In contrast, in its long form adiponectin trimers form hexamers (intermediate or medium molecular weight form or 2.1.1. Adiponectin Gene Adiponectin, also known as ACRP30 (adipocyte complement-related protein of 30 kDa), GBP28 (Gelatin-binding protein 28), ADIPOQ (Adiponectin, C1Q And Collagen...