Adhesion G protein-coupled receptors (aGPCRs) are essential for a variety of physiological processes such as immune responses, organ development, cellular communication, proliferation and homeostasis1,2,3,4,5,6,7. An intrinsic manner of activation that involves a tethered agonist in the N-terminal...
While control cells showed rapid and transient activation of VLA-4, cells preactivated through Gαs-coupled receptor showed a significantly lower response (Fig. 1A). Although, a slight decrease in the LDV-FITC binding to the resting cells after Gαs-coupled receptor stimulation was observed, ...
A. The N terminus of the adhesion G protein-coupled receptor GPR56 controls receptor signaling activity. J. Biol. Chem. 286, 28914–28921 (2011). 17. Lein, E. S. et al. Genome-wide atlas of gene expression in the adult mouse brain. Nature 445, 168–176 (2007). 18. Cahoy, J. ...
We also show that ARM-1 is a cytosolic protein associated with the plasma membrane. However, no cell surface expression of the protein was observed. These results suggest an indirect role of ARM-1 in adhesion rather than a direct role as an adhesion molecule itself. 展开 关键词: adhesion-...
However, the induction of HEF1 phosphorylation by G protein-coupled receptors has not been reported. We found that HEF1, but not p130Cas, is tyrosine-phosphorylated following stimulation of the rabbit C1a calcitonin receptor stably expressed in HEK-293 cells. The calcitonin-induced tyrosine ...
Purpose/Aim of the study: To explore the possible role of vascular adhesion protein-1 (VAP-1) via its enzymatic function as a semicarbazide-sensitive amine oxidase (SSAO) in the pathogenesis of proliferative diabetic retinopathy (PDR). Materials and Methods: The levels of soluble VAP-1/SSAO an...
Direct protein-protein interactions of trophinin, tastin, and bystin analyzed by yeast two-hybrid assays and by in vitro protein binding assays indicated that binding between bystin and trophinin and between bystin and tastin is enhanced when cytokeratin 8 and 18 are present as the third molecule....
TGF-β1 Slows the Growth of Pathogenic Myofibroblasts through a Mechanism Requiring the Focal Adhesion Protein, Hic-5 - ScienceDirect G Dabiri,DA Tumbarello,CE Turner,... - 《Journal of Investigative Dermatology》 被引量: 0发表: 2008年 Differential regulation of TGF-_ signal in hepatic ...
Our findings reveal a novel connection between ADGRF5, an adhesion G protein-coupled receptor, and the orchestration of the TME, which dictates malignancy progression. Overall, the data underscore ADGRF5 as a promising therapeutic target for breast cancer intervention....
FAK is also activated by several external stimuli, including activation of growth factor receptors or G protein-coupled receptors, and mechanical stress31–34. Although FAK is phosphorylated at multiple sites in response to stimuli, Y397 phosphorylation (pY397) is important for the proper integration...