这些蛋白质通过自身催化蛋白水解作用裂解为一个大的细胞外亚基和七跨度跨膜亚基,它们在细胞表面以受体复合物的形式结合。编码的蛋白可能在细胞粘附以及白细胞募集,激活和迁移中发挥作用,并且包含多个细胞外EGF样重复序列,这些重复介导与硫酸软骨素和细胞表面补体调节蛋白CD55的结合。该基因的表达可能在几种类型的癌症的进...
The encoded protein may play a role in cell adhesion as well as leukocyte recruitment, activation and migration, and contains multiple extracellular EGF-like repeats which mediate binding to chondroitin sulfate and the cell surface complement regulatory protein CD55. Expression of this gene may play ...
The encoded protein may play a role in cell adhesion as well as leukocyte recruitment, activation and migration, and contains multiple extracellular EGF-like repeats which mediate binding to chondroitin sulfate and the cell surface complement regulatory protein CD55. Expression of this gene may play ...
and contains multiple extracellular EGF-like repeats which mediate binding to chondroitin sulfate and the cell surface complement regulatory protein CD55.Expression of this gene may play a role in the progression of several types of cancer.Alternatively spliced transcript variants encoding multiple ...
Finally, ADGRE5 interacts with CD55 [60,61,62,63], the glycosaminoglycan chondroitin sulfate [64, 65], integrin [66] or CD90 [67] in an isoform-specific manner. Initial functional studies suggest that ADGRE5 is relevant for cell adhesion, migration and invasion [53, 59, 68]. To ...
The receptor is expressed as three alternatively spliced isoforms characterized by the presence of three to five EGF like motifs that play important roles in the binding of differents cells partners, including integrins, CD55 and chondroitin sulfate B. Interstingly, despite their ability to bind to...
Effective glioblastoma (GBM) treatment is limited by high invasiveness and heterogeneity. Current therapies target proliferating Glioma Stem Cell (GSC) subpopulations while sparing invading GSCs, which eventually engender tumor recurrence after treatment. Surface receptor CD97/ADRGE5 is associated with invas...
CD97/ADGRE5 is an adhesion G protein-coupled receptor (aGPCR) involved in tumor cell adhesion, migration, angiogenesis, and apoptosis. CD97 has been shown previously to stimulate angiogenesis by interacting with integrins on endothelial cells via an Argi
As the known interacting partners of aGPCRs are usually tethered to other cells, their identification and characterisation have been difficult. Of those identified, including CD55 for CD978, transglutaminase II (TGII) for GPR569and chondroitin sulphate B (dermatan sulphate) for EMR210, few had ...
Whereas TNF-alpha and IFN-gamma upregulated CD97, TGF-beta decreased CD97 expression. Due to interaction with CD55, ARPE-19 cells firmly adhered to monocytes and T lymphocytes when overexpressing CD97, suggesting a role for CD97 in controlling leukocyte infiltration across the RPE-based blood-...