The adenovirus life cycle consists of an early phase and a late phase, the first of which encompasses genes that are responsible for expressing mainly nonstructural, regulatory proteins, while the latter of which is focused on producing sufficient quantities of structural proteins to pack genetic ...
Life Cycle of Adenovirus The virus life cycle initiates with attachment to cell surface receptors. (1) Attachment: The virus attaches to the cell surface receptors through the interaction of the pentons with alphaVbeta3 and alphaVbeta5 integrin proteins. (2) Internalization: It is subsequently ...
The adenovirus life cycle involves early and late temporal phases. The early phase provides helper functionality for rAAV production, whilst the late phase is responsible for the production of adenoviral structural proteins8,9,10. These proteins are mainly transcribed from the adenovirus major late pr...
Therefore, expression of p53 at late stages of the viral life cycle might be not deleterious to virion progeny production. To explore this strategy, Sauthoff et al233 constructed a replicating Ad vector (Adp53rc) that contains the p53 cDNA inserted into the adenoviral fiber transcription unit, ...
E1A proteins are among the first to be expressed after adenoviral infection for initiation of the viral life cycle, cell cycle modulation, and transactivation of viral and cellular genes. Normally, adenoviruses can infect and propagate in dormant cells in which the E1A CR2 interacts with the reti...
The primary epidemiological concern with this parasite is its ability to have a direct life cycle and so birds kept indoors and away from the intermediate host may still become infected. Capillaria that infect the crop, esophagus, and oral cavity burrow into the mucosa, creating tracts that ...
Proteolytic maturation involving cleavage of one nonstructural and six structural precursor proteins including pVIII by adenovirus protease is an important aspect of the adenovirus life cycle. The pVIII encoded by bovine adenovirus 3 (BAdV-3) is a protein of 216 amino acids and contains two potenti...
E1A proteins are among the first to be expressed after adenoviral infection for initiation of the viral life cycle, cell cycle modulation, and transactivation of viral and cellular genes. Normally, adenoviruses can infect and propagate in dormant cells in which the E1A CR2 interacts with the reti...
The life cycle of adenovirus does not require integration into the host cell genome. The foreign genes delivered by adenovirus vectors are episomal and, therefore, have low genotoxicity to host cells. No side effects have been reported in studies of vaccination with wild-type adenovirus (Couch et...
The life cycle of adenovirus does not require integration into the host cell genome. Modifications of oncolytic adenovirus described herein may be made to improve the ability of the oncolytic adenovirus to treat cancer. Such modifications of an oncolytic adenovirus have been described by Jiang et al...