Berns KI, Cheung AK-M, Ostrove JM, Lewis M (1982) Adeno-associated virus latent infection. In Mahy BWJ, Minson AC, Darby GK (eds) Virus Persistence. Cambridge University Press, Cambridge, p 249Berns KI, Cheung A, Ostrove J, Lewis M. 1982. Adeno-associated virus latent infec- tion. ...
AAV, adeno-associated virus; ALT, alanine aminotransferase; SAE, serious adverse event. ∗ Reported in phase III trials. Virology and mechanism of AAV transfection AAVs are 20 nanometer, icosahedral structures of the Parvoviridae family that were first discovered as a contaminant in adenovirus prep...
Adeno-associated virus (AAV) has emerged as a pivotal delivery tool in clinical gene therapy owing to its minimal pathogenicity and ability to establish long-term gene expression in different tissues. Recombinant AAV (rAAV) has been engineered for enhanced specificity and developed as a tool for ...
Recombinant adeno-associated virus (rAAV) shows great promise for gene therapy, however scalability, yield and quality remain significant issues. Here we describe an rAAV manufacturing strategy using a ‘helper’ adenovirus that self-inhibits its major late promoter (MLP) to truncate its own replica...
Adeno-Associated Virus (AAV) is a type of virus that, unlike adenovirus, has a small genome size of approximately 5 kb. It is commonly used as a vector for gene delivery in various studies, including the development of vaccines and gene-based antibody delivery for protective immunity. ...
Therefore, gene therapy (GT) holds great promise for addressing the urgent need for innovative treatments in HCC. However, the complexity of HCC demands precise and effective therapeutic approaches. The adeno-associated virus (AAV) distinctive life cycle and ability to persistently infect dividing and...
An in vitro system to study the mechanism of site-specific integration of adeno-associated virus (AAV) was developed. This system is based on two substrates, a linear or circular AAV donor and a circular acceptor containing the preintegration locus AAVS1. In the presence of HeLa extract and ...
Adeno-associated virus (AAV) is one of the most actively investigated gene therapy vehicles. It was initially discovered as a contaminant of adenovirus preparations [4,5], hence its name. Simply put, AAV is a protein shell surrounding and protecting a small, single-stranded DNA genome of appro...
Asklepios BioPharmaceutical, Inc. (AskBio), a wholly-owned and independently-operated subsidiary of Bayer AG, today announced that the FDA's approval of a new adeno-associated virus (AAV) gene therapy to treat adults with hemophilia B ma...
Recombinant adeno-associated viruses (rAAVs) have emerged as promising gene therapy vectors due to their proven efficacy and safety in clinical applications. In non-human primates (NHPs), rAAVs are administered via suprachoroidal injection at a higher do