Richardson SI于2022年在Cell Host & Microbe期刊发表的文章《SARS-CoV-2 Omicron triggers cross-reactive neutralization and Fc effector functions in previously vaccinated, but not unvaccinated, individuals》中,使用InvivoGen的Jurkat-Lucia NFAT-...
ADCP FcγRIIa(131H) Jurkat GFP Effector Cell LineADCP Reporter细胞系选择了ADCP作用机制通路激活过程中较早的事件作为检测的读出指标:即效应细胞中由 NFAT通路介导的基因转录的激活。此外,ADCP报告基因检测试剂盒使用工程改造的 Jurkat 细胞作为效应细胞,该细胞稳定表达了FcγRIIa受体(高亲和131H)和由NFAT应答元件...
Fab段可以与特定的抗原结合,由此决定抗体的特异性和亲和力;Fc段可以与免疫细胞表面表达的Fc受体(FcγRI,FcγRII,FcγRIII)、血液中的补体(C1q)和FcRn结合,从而激活免疫效应细胞清除外来物。 抗体的结构决定其作用机制,Fab段可以识别游离分子和细胞表面的受体,决定抗体...
效应细胞(Effector Cells):如自然杀伤细胞(NK细胞)、巨噬细胞、中性粒细胞等,这些细胞能够通过Fc受体识别并结合到已结合有抗体的目标细胞上,进而引发细胞毒性作用。 Fc受体(Fc Receptor):存在于效应细胞表面的受体,能够与抗体上的Fc段结合,从而触发ADCC过程。 靶细胞(Target Cell):被抗体识别的细胞,通常是病毒感染的...
Mouse ADCC Bioassay Effector Cell 报告基因药靶模型很好的模拟了体内 ADCC 的信号转导过程,原理见下图所示。 Figure 1. Mouse ADCC Bioassay Effector Cell 模型原理图 III. Introduction Host Cell: Jurkat Expressed gene: FcγRⅣ Stability: 32 passages (in-house test, that not means the cell line will...
ADCP FcγRIIa(131H) Jurkat GFP Effector Cell Line ADCP Reporter细胞系选择了ADCP作用机制通路激活过程中较早的事件作为检测的读出指标:即效应细胞中由 NFAT通路介导的基因转录的激活。此外,ADCP报告基因检测试剂盒使用工程改造的 Jurkat 细胞作为效应细胞,该细胞稳定表达了FcγRIIa受体(高亲和131H)和由NFAT应答元...
6.Claudio Sustmann , Steffen Dickopf , Jörg T Regula, et al. DuoMab: a novel CrossMab-based IgG-derived antibody format for enhanced antibody-dependent cell-mediated cytotoxicity. MAbs. 2019, 11, 1402-1414. 7.Smith, K., Clatworthy, M. FcγRIIB in autoimmunity and infection: evolutiona...
ADCC FcγRIIIa(158V) Jurkat Effector Cell Line ADCC Reporter细胞系选择了ADCC作用机制通路激活过程中较早的事件作为检测的读出指标:即效应细胞中由 NFAT通路介导的基因转录的激活。此外ADCC报告基因检测试剂盒使用工程改造的 Jurkat 细胞作为效应细胞,该细胞稳定表达了FcγRIIIa受体(158F/158V)和由NFAT应答元件...
1. van der Horst HJ, Nijhof IS, Mutis T, Chamuleau MED. Fc-Engineered Antibodies with Enhanced Fc-Effector Function for the Treatment of B-Cell Malignancies. Cancers (Basel). 2020 Oct 19;12(10):3041. doi: 10.3390/cancers12103041. PMID: 33086644; PMCID: PMC7603375. ...
The effector cell(s) in human antibody-dependent cell cytotoxicity (ADCC). with antibody-coated chicken erythrocytcs as targets, was studied by comparison of cell suspensions from various lymphoid organs and by means of various cell fractionation methods. Effector cells (K) were found mostly in ...