Editing may regulate RNA abundance and fate by changing the local structure22. This may change the stability of the RNA duplex, affect structural determinants recognized by trans-acting factors and can change accessibility of factors to defined regions23,24,25. As even a single-nucleotide variant ...
The RNA-editing enzyme ADAR1 is essential for the suppression of innate immune activation and pathology caused by aberrant recognition of self-RNA, a role it carries out by disrupting the duplex structure of endogenous double-stranded RNA species1,2
Adenosine-to-inosine RNA editing constitutes a crucial component of the cellular transcriptome and critically underpins organism survival and development. While recent high-throughput approaches have provided comprehensive documentation of the RNA editom
Journal of Virus EradicationRadetskyy R, Chukwurah E, Daher A et al. A multiprotein complex with RNA binding proteins ADAR1, PACT, Tat and PKR contribute to low innate immunity against HIV-1. J Virus Erad 2016; 2 (Suppl 1): 9 (abstract 05)....
23,24,25,26 ADAR1 introduces A-to-I RNA modifications, which destabilize the dsRNA structure and then avoid recognition by MDA5 and PKR as well as prevent the activation of IFN signaling.27,28 Indeed, concurrent deletion of MDA5 and PKR can completely rescue embryo death and reverse the ...
& Rich, A. Structure of the DLM-1–Z-DNA complex reveals a conserved family of Z-DNA-binding proteins. Nat. Struct. Biol. 8, 761–765 (2001). Article CAS PubMed Google Scholar Herbert, A. Z-DNA and Z-RNA in human disease. Commun. Biol. 2, 7 (2019). Article PubMed PubMed ...
Therefore, as the core complex of m6A is formed by METTL3 and METTL14, with the first carrying the catalytic subunit and the latter being an essential factor facilitating the RNA binding, we analyzed the presence/level and cell localization of both METTL3 and METTL14 in GBM. ...
ADAR1 forms a complex with dicer to promote microRNA processing and RNA- induced gene silencing. Cell. 2013;153:575-89. https://doi.org/10.1016/j.cell. 2013.03.024.Ota, H., M. Sakurai, R. Gupta, L. Valente, B. E. Wulff et al., 2013 ADAR1 forms a complex with Dicer to ...
The RNA-editing enzyme adenosine deaminase acting on RNA 1 (ADAR1) limits the accumulation of endogenous immunostimulatory double-stranded RNA (dsRNA)1. In humans, reduced ADAR1 activity causes the severe inflammatory disease Aicardi–Goutières syndrome (AGS)2. In mice, complete loss of ADAR1 ...
Newly transcribed RNA usually dissociates from its template DNA strand immediately after transcription, but occasionally it forms a stable RNA:DNA hybrid, which consequently leaves the sense DNA in a single-stranded form. This structure, called an R-loop, often spans 100–2000 bp and causes ab...