“adaptive”,英文原意是指能够适应变化或者改变以适应新情况的能力,在抗肿瘤治疗中,“adaptive treatment(适应性治疗)”,即根据不同治疗场景的特征,在原有标准治疗方案的基础上做出适应性改变,在毒性可耐受的基础上获得更好的疗效。本文分别从早期肺癌、局部晚期肺癌...
因此,临床实践呼唤能够随着每日解剖学变化而变化的治疗方案,做到“敌变我变,如影随形”。 自1997年首次自适应放射治疗(Adaptive radiation therapy)的概念至今,自适应放射治疗经过多年发展,伴随着医学人工智能技术的火热和在临床的逐步应用,以AI技术为基石,整合全流程的在线自适应放疗平台正式推出,为放射治疗领域增加了...
其拥有的TruTCR T细胞受体(TCR)筛查平台可通过免疫测序和其他技术来鉴定和表征有效结合靶抗原的TCR。 TCR-T疗法是一种过继免疫细胞治疗(Adoptive Cell Transfer Therapy,ACT)。过继免疫细胞治疗是指从肿瘤患者体内分离免疫活性细胞,在体外进行扩增和功能鉴定,然后向患者回输,从而达到直接杀伤肿瘤或激发机体的免疫应答杀伤...
参考文献: Wilkoff BL, Filippatos G, Leclercq C, et al. Adaptive versus conventional cardiac resynchronisation therapy in patients with heart failure (AdaptResponse): a global, prospective, randomised controlled trial [published correction appears in Lancet. 2023 Sep 30;402(10408):1132]. Lancet. ...
TCR-T疗法是一种过继免疫细胞治疗(Adoptive Cell Transfer Therapy,ACT)。过继免疫细胞治疗是指从肿瘤患者体内分离免疫活性细胞,在体外进行扩增和功能鉴定,然后向患者回输,从而达到直接杀伤肿瘤或激发机体的免疫应答杀伤肿瘤细胞的目的。 TCR-T疗法的基本步骤是:首先鉴定出一种或多种肿瘤抗原作为治疗靶点,再获得特异识别...
1)Adaptive radiation therapy自适应放疗 1.Adaptive radiation therapywas developed to compensate for setup error and organ motion.自适应放疗(Adaptive Radiotherapy,ART)是图像引导放射治疗(image-guided radiotherapy,IGRT)提高和发展后的新型放疗技术。
The goal of adaptive therapy is to enforce a stable tumor burden by permitting a significant population of chemosensitive cells to survive so that they, in turn, suppress proliferation of the less fit but chemoresistant subpopulations. Computer simulations show that this strategy can result in ...
Adaptive Therapy A number of successful systemic therapies are available for treatment of disseminated cancers. However, tumor response is often transient, and therapy freq... RA Gatenby,AS Silva,RJ Gillies,... - 《Cancer Research》 被引量: 578发表: 2009年 Biological response to radiation therap...
In this Perspective article, we discuss why defining AIR mechanisms at the tumour site should be a key focus to direct future drug development as well as practical approaches to improve current cancer therapy. This is a preview of subscription content, access via your institution Access options ...
Weekly volume and dosimetric changes during chemoradiotherapy with intensity-modulated radiation therapy for head and neck cancer: a prospective observational study Int J Radiat Oncol Biol Phys., 76 (5) (2010), pp. 1360-1368 View in ScopusGoogle Scholar [7] S. Strand, A. Boczkowski, B. Smit...