Adaptive immunity depends on specialized population of antigen-specific lymphocytes, the B and T lymphocytes. In this thesis proposal, I have investigated the role of complement and double-stranded RNA-dependent interferon inducible protein kinase, PKR, in regulating antigen-specific T cell responses ...
‘Adaptive immunity’ is defined as the aspect of the immune response that is initiated, via either immunoglobulins or T cell receptors (TCRs), by recognition of foreign antigens. From: Encyclopedia of Immunobiology, 2016 About this pageSet alert On this page Definition Chapters and Articles Rela...
Induction of adaptive immunity not only depends on direct antigen recognition by the antigen receptors but also relies on essential signals that are delivered by the innate immune system. In recent years, we have witnessed the discovery of a still expanding array of different PRR systems that ...
and they are associated with CXCL5 in innate immune stimulations (Fig.1c). These observations are supported by previous findings showing that smoking favours inflammation and compromises immunity to bacterial infection13, and that IL-2 and IL-13 are involved in modulating ...
Type I interferons (IFNs), the primary innate cytokines that control virus growth and spreading, can influence various aspects of adaptive immunity. The development of antiviral immunity depends on many viral and cellular factors, and the extent to which type I IFNs contribute to the generation ...
T lymphocytes expressing γδ T cell antigen receptors (TCRs) comprise evolutionarily conserved cells with paradoxical features. On the one hand, clonally expanded γδ T cells with unique specificities typify adaptive immunity. Conversely, large compartments of γδTCR+intraepithelial lymphocytes (γδ...
Accumulating evidence strongly supported the direct and indirect regulatory effects of neutrophils on adaptive immunity. Exogenous cytokines or cytokines produced in an autocrine manner as well as a cell-to-cell contact between neutrophils and T cells could induce the expression of MHC-II and ...
Natural-killer (NK) cells are specialized lymphocytes that have cytotoxic properties in addition to their ability to produce cytokines that assist in the orchestration of adaptive immunity. In contrast to basic innate immunity, adaptive immunity is specific and depends on antigenic stimulation. Antigens...
001, Adaptive Immunity & Vaccination, RON2315: A novel human biologic for the topical treatment of psoriasis 002, Blockade for CD155-TIGIT interaction is an effective therapy for melanoma 003, Migratory DC temper subcutaneous immunity through key tolerance pathways 004, Rationale and design of a no...
This study shows that intestinal TH1 and TH17 immunity associated with the parasite T. musculis depends on IL-18 produced by hematopoietic-derived cells. Similarly, ASC is required for a TH1 response following T. musculis colonization. Article CAS PubMed PubMed Central Google Scholar Cox, M....