Adaptive design methods in clinical trials. Boca Raton: CRC Press; 2011.CHOW, S. AND CHANG, M. (2007). Adaptive Design Methods in Clinical Trials. Boca Raton: Chapman & Hall/CRC.Chow SC, Chang M. Adaptive design methods in clinical trials. Boca Raton, FL: Chapman and Hall/CRC Press;...
These types of designs have sometimes been considered controversial in their use in pivotal studies. The last section of the chapter outlines why this could be true. It would also have been useful to have some description of when these methods would be most applicable, or how to ensure the ...
Chow SC, Chang M (2012). Adaptive Design Methods in Clinical Trials. Boca Raton: Chapman & Hall/CRC Biostatistics Series.Chow SC, Chang M (2012) Adaptive Design Methods in Clinical Trials. (2ndedn), Chapman Hall/CRC Press, Taylor and Francis, New York...
In recent years, the potential use of adaptive design methods in clinical trials have attracted much attention. The Pharmaceutical Research and Manufacturers of America (PhRMA) and Biotechnology Industry Organization (BIO) have established adaptive design working groups and proposed strategies, methodologies...
Adaptive design methods in clinical trials. Shein-Chung Chow and Mark Chang, Chapman & Hall/CRC, Boca Raton, FL, 2007. No. of pages: 277. Price: $89.95. ISBN10 1-58488-776-1, ISBN13 978-1-58488-776-8 - ResearchGate F Miller,SJ Wiklund - 《Statistics in Medicine》 被引量: 0发表...
Adaptive design methods in clinical trials. CRC; 2011. Bothwell LE, Avorn J, Khan NF, Kesselheim AS. Adaptive design clinical trials: a review of the literature and ClinicalTrials.gov. BMJ open. 2018;8(2):e018320. Article PubMed PubMed Central Google Scholar Bauer P, Einfalt J. ...
bayesian adaptive designs for early phase clinical trials:早期临床试验的贝叶斯自适应设计 热度: CLINICAL TRIALS –临床试验– 热度: Bayesian Adaptive Designs in Phase III Clinical Trials 热度: BayesianAdaptiveMethodsfor ClinicalTrials ScottM.Berry,BradleyP.Carlin,J.JackLee,andPeterM¨uller ...
Mark Chang, author of Adaptive Design Methods in Clinical Trials, Second Edition on crcpress.comCRC Press - Featured Authors
In such trials, patients are randomised to either receive the standard chemotherapy treatment or a biomarker-directed treatment arm, in which biomarker status is used to guide treatment. Methods: Motivated by a current trial, we consider an adaptive design in which two biomarkers are assessed. The...
Chang Adaptive design methods in clinical trials—a review Orphanet J Rare Dis, 3 (2008), p. 11 View in ScopusGoogle Scholar 43 P. Bauer Multistage testing with adaptive designs Biomet Informatik Medizin Biol, 20 (1989), pp. 130-148 CrossrefGoogle Scholar 44 P. Bauer, K. Kohne ...