Adapalene‐benzoyl peroxide (BPO), clindamycin‐BPO and clindamycin‐tretinoin demonstrated the greatest reduction in non‐inflammatory (ratio of means [RoM] 1.76; 95% CI [1.46; 2.12], RoM 1.70; 95% CI [1.44; 2
Benzoyl peroxide Benzoyl peroxide is a topical organic peroxide with antibacterial and comedolytic properties Fulton et al (1974). Patients will likely experience erythema and irritation with its use. These effects usually diminish with continued use of the product. Clindamycin Clindamycin is a topical...
Topical clindamycin phosphate 1.2%/adapalene 0.15%/benzoyl peroxide (BPO) 3.1% gel (IDP-126) is the first fixed-dose triple-combination in development for acne. Objective: To confirm efficacy, safety, and tolerability of IDP-126 gel in acne treatment. Methods: Two phase 3, double-blind, 12...
Adapalene 0.1%/benzoyl peroxide 2.5% gel did not significantly differ from clindamycin 1%/benzoyl peroxide 5% gel in terms of the reduction in the inflammatory, noninflammatory, or total lesion counts in patients with mild to moderate acne, according to the results of a 12-week trial. Twelve-...
Exposure of adapalene to other topical anti-acne drugs such as erythromycin, clindamycin phosphate or benzoyl peroxide does not produce any mutual degradation. Absorption of adapalene through human skin is low (see section 5.2 Pharmacokinetic properties) and therefore interaction with systemic medication ...
agent or contraction irritating substances can cause additional irritation. Therefore, use other skin medication early in the morning such as erythromycin (concentrations ≤4%), clindamycin phosphate (1%) aqueous solution or benzoyl peroxide gel (concentration ≤10%); Use Duff Man gel at night so ...
Jelvehgari, M., Siahi-Shadbad, M. R., Azarmi, S., Martin, G. P. & Nokhodchi, A. The microsponge delivery system of benzoyl peroxide: Preparation, characterization and release studies.Int. J. Pharm.308, 124–132 (2006). ArticleCASPubMedGoogle Scholar ...
Jelvehgari, M., Siahi-Shadbad, M. R., Azarmi, S., Martin, G. P. & Nokhodchi, A. The microsponge delivery system of benzoyl peroxide: Preparation, characterization and release studies.Int. J. Pharm.308, 124–132 (2006). ArticleCASPubMedGoogle Scholar ...
It references a study by A. Langner et al. published in the January 2008 issue of the "British Journal of Dermatology." Results showed that benzoyl peroxide/clindamycin has an earlier onset of action, is better tolerated and is more effective against lesions.EBSCO_AspInpharma Weekly...
Data indicate that 0.1% adapalene gel is effective in combination with topical clindamycin or benzoyl peroxide or oral cyclines (lymecycline, minocycline) in reducing the number of inflammatory and noninflammatory lesions in patients with mild-to-moderate or moderate to moderately severe acne vulgaris....