ADAMTS9-AS2 is an example of lncRNAs with different roles in human disorders. It is mostly acknowledged as a tumor suppressor lncRNA in different types of cancers. However, it has been reported to be up-regulated in tongue squamous cell carcinoma, salivary adenoid cystic carcinoma and ...
ADAMTS9-AS2 is located at the positive strand of chromosome 3 (chr3: 64, 684, 935-65, 053, 439) with length of 2.258 kb. As shown inFigure 1A, ADAMTS9-AS2 is well conservative among different species, indicating its potential of regulatory functions in different species. PhyloCSF analysis...
We identified the promoter region of Annexin A1 as the major target of ADAMTS9-AS2. The binding of lncRNA ADAMTS9-AS2 to the promoter region can facilitate the expression of tumor suppressor Annexin A1 thereby decrease the proliferation and increase apoptosis of cancer cells. Collectively, our ...
ADAMTS9-AS2 expression in BC tissues, para-cancerous tissues, as well as MCF-7 and MCF-7R cells, was accessed by quantitative Real Time-Polymerase Chain Reaction (qRT-PCR). The correlation between ADAMTS9-AS2 expression with pathological grade and tumor size of BC was explored. Chromatin ...
LncRNA ADAMTS9-AS2肝母细胞瘤增殖转移上皮间质转化目的:探索LncRNA ADAMTS9-AS2在肝母细胞瘤中的表达情况,并探究其对肝母细胞瘤细胞增殖,侵袭,转移能力和上皮间质转化(EMT)进程的调控作用.方法:采用RT-qPCR方法检测45对肝母细胞瘤组织以及外周正常组织中LncRNA ADAMTS9-AS2的表达,同时分析与患儿临床病...
ADAMTS9‐AS2EMTmetastasisOSCCOSFOral submucosal fibrosis (OSF) is one of the preヽancerous lesions of oral squamous cell carcinoma (OSCC). Its malignant rate is increasing, but the mechanism of malignancy is not clear. We previously have elucidated the long nonヽoding RNA (lncRNA) expression ...
Low ADAMTS9-AS2 expression was correlated with advanced FIGO stage, lymph-node metastasis, and poor overall survival of OC patients. Function assays showed that ADAMTS9-AS2 reduced OC cells proliferation, invasion, and epithelial-mesenchymal transition (EMT) processes in vitro and restrained tumor ...
ADAMTS9‐AS2cancer stem cellsgastric cancerSpeckle‐type POZ proteintumorsphereNowadays, research on CSCs is still in an initial stage, and there are few studies reporting the successful isolation and identification of CSCs. In the present study, we attempted to isolate CSCs through cultivating the ...
ADAMTS9-AS2 is a lncRNA that has been widely studied in tumors, but not in ischemic stroke. The purpose of this study was to investigate the role and potential molecular mechanism of ADAMTS9-AS2 in endothelial cell function after ischemic stroke in vivo and in vitro. The results showed ...