长链非编码RNA ADAMTS9-AS1对非小细胞肺癌细胞侵袭迁移和Wnt信号通路的影响
High ADAMTS9-AS1 level was associated with TNM stage, lymph node invasion and worse survival prognosis. Depletion of ADAMTS9-AS1 significantly suppressed cell proliferation, G1/S transition, migration and invasion, as well as suppressed CDK4/Cyclin D1 and epithelial-mesenchymal transition (EMT). ...
We screened and identified a novel lncRNA, ADAMTS9-AS1, which was significantly decreased in colorectal cancer tissues and was correlated with clinical outcome of patients according to The Cancer Genome Atlas (TCGA) database. In addition, ADAMTS9-AS1 regulated cell proliferation and migration both ...
Functionally, ADAMTS9-AS1 knockdown in ectopic ESCs (EESCs) decreased cell viability and migration, whereas ADAMTS9-AS1 overexpression in normal ESCs (NESCs) enhanced cell viability and migration. More importantly, the effect of ADAMTS9-AS1 inhibition on decreasing ESC viability was significantly ...
ADAMTS9-AS1ADAMTS9HuRccRCCCell growthThe lack of efficacious treatments for clear cell renal cell carcinoma (ccRCC) has led to a poor 5-year survival rate. Here, we found that the expression of ADAM metallopeptidase with thrombospondin type 1 motif 9 (ADAMTS9) antisense RNA 1 (ADAMTS9-AS1)...
ADAMTS9-AS1Apoptosis and autophagyPI3KAKTmTOR signaling pathwayBladder cancer is the most common cancer in the urinary system which has threatened lives. Increasing evidence has shown that lncRNAs were expressed in cancer cells as a biomarker and might regulate cancer cell development and progression. ...
ADAMTS9‐AS1miR‐142‐5pCCND1Emerging evidence has implied the importance of long non‐coding RNAs in cancer development, including prostate cancer (PCa). Bioinformatic analyses have identified that ADAMTS9‐AS1 may play a role in cancer progression....
结果 ADAMTS9-AS1高表达的胰腺癌患者较低表达患者有更高的生存率(P=0.010).ADAMTS9-AS1相关性较强的差异mRNA,GO富集结果共筛选到356个条目,结果与免疫相关,如白细胞-细胞黏附,肿瘤坏死因子超家族细胞因子产生的调控等;KEGG结果共筛选到9个通路,分别为金黄色葡萄球菌感染,细胞周期,补体和凝血级联,卵母细胞减数分裂...
目的 研究乳腺癌组织中长链非编码RNA(LncRNA)ADAMTS9-AS1,miR-513 a-5 p的表达,并分析二者的关系及临床意义.方法 选取2015年8月—2017年8月诊治的乳腺癌患者83例为研究对象.应用实时定量PCR检测乳腺癌及癌旁组织中LncRNA ADAMTS9-AS1,miR-513 a-5 p的表达.Pearson相关分析二者的相关性,在线生物信息学软件...
Long non‐coding RNA ADAMTS9‐AS1 inhibits the progression of prostate cancer by modulating the miR‐142‐5p/CCND1 axisdoi:10.1002/jgm.3331Zhou, ZhienWu, XingchengZhou, YiYan, WeigangJournal of Gene Medicine