MECHANISM OF ACTION : ADAMTS-13 protease agonist.doi:EP1568782 A1KENTOUCHE, KARIM, DR. MED.BRUNKHORST, FRANK MARTIN, DR. MED.CLAUS, RALF ALEXANDER, DR. RER.NAT.DEIGNER, HANS-PETER, DR. RER.NAT.REINHART, KONRAD, PROF. DR. MED.
The mode of action of ADAMTS13 is unusual inasmuch as proteolysis is dictated by shear-dependent conformational changes in the substrate (VWF), as opposed to on-demand activation of the enzyme13. Classically, plasma protease zymogens (e.g., complement, hemostatic, fibrinolytic proteases) are prot...
25 and autoimmune disorders such as systemic lupus erythematosus.26 In addition, a number of other disorders are also associated with thrombotic microangiopathy (TMA). These diseases often exhibit
Binding of ADAMTS13 to the VWF D4(-CK) domains or to certain activating murine monoclonal antibodies (mAbs) induces a structural change that extends ADAMTS13 into an open conformation that enhances its function. The objective was to characterize the mechanism by which conformational activation ...
ADAMTS13 conformations and mechanism of inhibition in immune thrombotic thrombocytopenic purpura. J. Thromb. Haemost. 2022, 20, 2197–2203. [Google Scholar] [CrossRef] [PubMed] Halkidis, K.; Siegel, D.L.; Zheng, X.L. A human monoclonal antibody against the distal carboxyl terminus of ...