Resistance to anti-influenza drugs: adamantanes and neuraminidase inhibitors. Expert Rev Anti Infect Ther 2006 Oct; 4 (5): 795-805Hurt AC,Ho HT,Barr I. Resistance to anti-influenza drugs: adamantanes and neuram
It can be expected that these drugs would be able not only to compen- sate or restore the lost cognitive functions, but also to suppress further development of the neurodegenerative process9–12. It is known that the key neurobiological aspects affected by the AD development are the cholinergic...
resulting in considerable enhancement of the overall pharmacological effect, and to provide these drugs with both cognitive-stimulating and disease-modifying action. It is believed that the development of a single chemical molecule able to act simultaneously...
The 1-aminoadamantanes memantine (1-amino-3,5-dimethyl-adamantane) and amantadine (1-amino-adamantane) are clinically used as antiparkinsonian, anti-spasticity, anti-dementia and antiviral drugs. In the present investigation we have tested a series of 1-aminoadamantane derivatives including memantine...
Wang JF, Wei DQ, Chou KC (2009) Insights from investigating the interactions of adamantane-based drugs with the M2 proton channel from the H1N1 swine virus. Biochem Biophys Res Commun 388(2):413–417 Article CAS Google Scholar Bubnov YN, Gursky ME, Pershin DG (1991) A novel method of...
Moreover, in present days, it was reliably useful for the revision of absolute structures for some known drugs [18,19]. Afterwards, Zn-tpt MOF, as crystalline sponge, has been functional for many other compounds like crude natural oils [8], camphene & pinenes [20], benzodioxazoles [21]...
Surprisingly, Aminoadamantane and Cyclohexylamine drugs such as memantine, tromantadine and neramexane have been found to exhibit significant antimicrobial activity at concentrations which are useful for pharmaceutical formulation purposes. In one embodiment, the composition of the invention is substantially ...
not commonly used in the synthesis of proprietary drugs, but are also very severe—with the consequent danger of impurity formation which then must be removed by often laborious purifications. Specifically referring to U.S. Pat. No. 3,391,142, the free base obtained following the hydrolysis is...
Adamantane drugs (e.g., memantine, rimantadine, and amantadine) consist of a core tricyclodecane with different substituents. Memantine is used for treatment of Alzheimer's disease, while rimantadine and amantadine are recommended for influenza A infection. Additionally, amantadine is clinically ...
Thus, these compounds can be regarded as promising candidates for the design of multi-target disease-modifying drugs for treatment of AD and/or similar neuropathologies.doi:10.1038/srep45627Sergey O. BachurinElena F. ShevtsovaGalina F. Makhaeva...