3K, L) and decreasing gene expression of ANP, BNP and the markers of cardiac hypertrophy, MyHC (Fig. 3M). Taken together, ADAM17 deletion decreases infarct size and enhances cardiac function in mice with post-MI HF. Fig. 3 Gene silencing of ADAM17 reduced infarct size and improve cardiac...
Fig. 3 Gene silencing of ADAM17 reduced infarct size and improve cardiac function in MI mice.ASchematic diagram of the experimental design. The ADAM17 inhibitor TAPI-1 or a comparable amount of DMSO were gavaged into mice on days 1, 3, 5, 7, and 14. Mice were sacrificed on day 30 a...