Apnimed is a clinical-stage pharmaceutical company working to transform the treatment of sleep apnea based on a simple idea – patients with obstructive sleep apnea could benefit from treatment with a safe and effective oral medication...
本研究已完成,并在 ClinicalTrials 注册。gov,NCT02918292. 研究结果 2017年05月01日至2020年08月30日期间,从14家美国中心入组了32例复发性或难治性重型再生障碍性贫血患者,其中31例接受了骨髓移植。中位年龄为24.9岁 (IQR 10.4~51.3...
However, virus-mediated gene therapies have demonstrated insufficient therapeutic efficacy in clinical trials due to rapid dissemination to nontarget tissues and to the immunogenicity of viral vectors, resulting in poor retention at the disease locus and induction of adverse inflammatory responses in ...
6. Lu, J., et al., Current comprehensive understanding of denosumab (the RANKL neutralizing antibody) in the treatment of bone metastasis of malignant tumors, including pharmacological mechanism and clinical trials. Front O...
In clinical trials in postmenopausal women, raloxifene had an estrogen-like effect on bone turnover and increased bone mineral density. It reduced the risk of fractures in women with osteoporosis. Raloxifene also seemed to reduce the risk of breast cancer and positively influenced blood lipid ...
Candidate HIV-1 vaccines currently being evaluated in clinical trials are designed to elicit HIV-1-specific cellular immunity. Intracellular cytokine stain... H Horton,EP Thomas,JA Stucky,... - 《Journal of Immunological Methods》 被引量: 320发表: 2007年 Intracellular cytokine optimization and stan...
胺碘酮临床试验荟萃分析(AmiodaroneTrialsMeta-Analysis，ATMA）研究(索引)EMIAT(8)CAMIAT(7)GEMICA(9)PAT(10)SSSD(11)BASIS(12)HOCKINGS(13)CAMIAT-P(14)CHFSTAT(15)GESICA(16)EPAMSA(17)NICKLAS(18)HAMER(19)总括 总死亡率 相关性检验P=0.030异源性检验P=0.058 0.87(95%Cl0.78~0.99)1/8 ...
目前在ClinicalTrials.gov网站上列出了超过9万项癌症试验,其中突出了两个主要问题:首先,没有足够的财政资源来测试所有可能的药物组合;其次,除了让患者接触具有潜在毒性且不太可能成功的药物组合似乎是不道德的观念之外,没有足够的患者来测试所有可能的药...
腹股沟疝是临床常见疾病,有研究结果显示,全球每年开展>2000万例腹股沟疝手术。为确保手术质量,进一步规范和提高我国腹股沟疝诊疗水平,中华医学会外科学分会疝与腹壁外科学组、中国医师协会外科医师分会疝和腹壁外科专家工作组组织国内相关专业部分专家,在《成人腹股...
Ototoxicity of Gentamicin in Man: A Survey and Controlled Analysis of Clinical Experience in the United States Ototoxicity from gentamicin was recognized early as a potential risk. From clinical trials in the U.S. between 1962 and 1969, a total of 72 courses of trea... GG Jackson,G Arcieri...