Articles Basic Science Investigation nature publishing group Analysis and interpretation of acylcarnitine profiles in dried blood spot and plasma of preterm and full-term newborns Antonina Gucciardi1, Patrizia Zaramella2, Irene Costa1, Paola Pirillo1, Daniel Nardo2, Mauro Naturale1, Lino...
The most clinically relevant interpretation of our results is that:1) more severe forms of depression, defined by high levels of sadness and anhedonia, are associated with reductions in short-chain acylcarnitines, and 2) depression characterized by reduced sleep and appetite show substantial ...
Dinesh Rakheja, in A Quick Guide to Metabolic Disease Testing Interpretation (Second Edition), 2020 4.2 Acylcarnitine profile Total carnitine is often elevated, with the majority or all of the carnitine being in the free form. Long-chain acylcarnitines (C16- and C18-) will usually be very low...
Data transformation using z-scores is not fully new in data interpretation [12, 31, 33]. However, for urine metabolites, robust data transformation method was used due to the large scale and variability across all measured analytes and the skewed distribution of the data including outliers. To ...
In case of retrospective, diagnostic analysis, examination of the complete acylcarnitine profile may allow for an estimate of the metabolite instability. This would improve the interpretation of potential deviations and could reveal outliers that would otherwise not have been discovered. Especially in ...
The funders had no role in the design of the study; in the collection, analyses, or interpretation of data; in the writing of the manuscript; or in the decision to publish the results. References David, G.; Dürr, A.; Stevanin, G.; Cancel, G.; Abbas, N.; Benomar, A.; Belal,...
Acylcarnitines profile of responders (n = 12) and non-responders (n = 10). Group differences were analyzed by conducting generalized estimating equation (GEE) after adjusting confounding effect of anticonvulsants. R: responders; NR: non-responders. 3.9. Free Carnitine and βHB Levels in ...